Document Detail

Brain proton magnetic spectroscopy in long-term treatment of Wilson's disease patients.
MedLine Citation:
PMID:  20838861     Owner:  NLM     Status:  In-Process    
We reported the brain proton magnetic resonance spectroscopy (MRS) findings in 27 Wilson's disease (WD) patients treated more than 6 years in neurological (nWD) and hepatic (hWD) subgroups. We investigated four hWD patients, with no improvement and eight with marked improvement; and eight nWD patients with marked improvement and seven with no improvement of clinical status. In nWD patients with improvement the MRS showed significantly higher Cho/Cr, Glx/Cr ratios levels. In hWD patients with no improvement the lower Cho/Cr and in nWD significantly lower NAA/Cr and higher Cho/Cr and Lip/Cr ratios were detected. In nWD patients with improvement the spectroscopic pattern, can be related to gliosis. In patients with no neurological improvement a persistent neuronal dysfunction can occur, perhaps as a result of copper or iron deposition.
Beata Tarnacka; Wojciech Szeszkowski; Marek Gołębiowski; Anna Członkowska
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-09-14
Journal Detail:
Title:  Metabolic brain disease     Volume:  25     ISSN:  1573-7365     ISO Abbreviation:  Metab Brain Dis     Publication Date:  2010 Sep 
Date Detail:
Created Date:  2010-11-04     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8610370     Medline TA:  Metab Brain Dis     Country:  United States    
Other Details:
Languages:  eng     Pagination:  325-9     Citation Subset:  IM    
II Department of Neurology, Institute of Psychiatry and Neurology, 9 Sobieskiego Str., Warsaw, Poland.
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