| Brain processing of visceral sensation upon esophageal chemical stimulation in different types of GERD. | |
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MedLine Citation:
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PMID: 20434286 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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We designed to investigate the cortical response to esophageal acid exposure in different types of gastroesophageal reflux disease (GERD) by functional magnetic resonance imaging (fMRI). Fifteen healthy volunteers, 13 with reflux esophagitis (RE), 12 with non-erosive reflux disease with abnormal acid reflux (NERD+) and nine with non-erosive reflux disease with normal acid reflux (NERD-) received intraesophageal perfusion with isotonic saline followed by 0.1 N hydrochloric acid. Modified block-design model of fMRI scanning was performed simultaneously to the intraesophageal perfusion. The sensitized regions in different types of GERD were not completely identical but were more widely distributed compared to the sensitized regions in the healthy individuals. The activated intensity of the ACC was significantly higher in the healthy volunteers compared to the GERD patients (P<0.001). Nevertheless, healthy volunteers exhibited a significantly lighter intensity in the right side of the DLPFC (P<0.001) and a lower intensity in the left side of the insula than the GERD patients (P<0.05). In conclusion, the underlying central mechanisms of esophageal visceral sensation in different types of GERD patients are quite different. The deactivation of the ACC, the activation of the right side of the DLPFC and the right side of the insula may play an important role in the occurrence of GERD. |
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Authors:
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ShuChang Xu; FangFang Zheng; XiaoHu Zhao; Ying Chen; Xuan Kong; Chen Wang; LiRen Zhu; ZhiYong Wang |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: European journal of radiology Volume: 75 ISSN: 1872-7727 ISO Abbreviation: Eur J Radiol Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-09-20 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8106411 Medline TA: Eur J Radiol Country: Ireland |
Other Details:
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Languages: eng Pagination: 352-9 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Elsevier Ireland Ltd. All rights reserved. |
Affiliation:
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Department of Gastroenterology, Tongji Hospital, Tongji University School of Medicine, Shanghai 200065, China. xschang@163.com |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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