Document Detail

Brain perfusion studies in the evaluation of acute neurologic abnormalities.
MedLine Citation:
PMID:  23414828     Owner:  NLM     Status:  In-Data-Review    
Two categories of single-photon radiopharmaceuticals for brain perfusion exist, nonlipophilic and lipophilic compounds. The former are useful in performing simple flow examinations which today have application primarily in the determination of brain death. The latter also exhibit a parenchymal uptake phase that allows for evaluation of the distribution of blood flow within the brain. The lipophilic radiopharmaceuticals, therefore, have application in the evaluation of patients following catastrophic brain injury and traumatic brain injury (TBI) and in prognosticating the outcome following cerebral vascular accidents. Use of these agents to monitor therapy with thrombolytic agents, although theoretically helpful, is technically difficult due to the need to institute treatment rapidly, without undue delay.
Lionel S Zuckier; O O Sogbein
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Seminars in nuclear medicine     Volume:  43     ISSN:  1558-4623     ISO Abbreviation:  Semin Nucl Med     Publication Date:  2013 Mar 
Date Detail:
Created Date:  2013-02-18     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  1264464     Medline TA:  Semin Nucl Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  129-38     Citation Subset:  IM    
Copyright Information:
Copyright © 2013 Elsevier Inc. All rights reserved.
Division of Nuclear Medicine, Department of Medicine, The Ottawa Hospital, University of Ottawa, General Campus, Ottawa, Ontario, Canada. Electronic address: LZuckier@TOH.ON.CA.
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