Document Detail

Brain perfusion differences in parkinsonian disorders.
MedLine Citation:
PMID:  21830234     Owner:  NLM     Status:  MEDLINE    
We aimed to objectively examine the brain perfusion differences between PD, Parkinson variant of multiple system atrophy, and progressive supranuclear palsy. (99m) Tc ethylcysteinate dimer single-photon emission CT (SPECT) was performed in 28 patients with PD, 12 with Parkinson variant of multiple system atrophy, 19 with progressive supranuclear palsy, and 17 age- and sex-matched control subjects. A voxel-by-voxel group analysis, using statistical parametric mapping 8, was performed to detect the differences of regional cerebral blood flow among three diseases and control groups. Regional cerebral blood flow was measured using the noninvasive Patlak plot method and calculated using a fully automated region of interest technique. Progressive supranuclear palsy showed decreased regional cerebral blood flow in the cingulate gyrus and thalamus, whereas Parkinson variant of multiple system atrophy showed decreased regional cerebral blood flow in the cerebellum, compared with other patients and controls. Regional cerebral blood flow in the thalamus could be used to discriminate progressive supranuclear palsy from other diseases and control subjects with high sensitivity. These findings suggest that parkinsonian disorders, such as PD, Parkinson variant of multiple system atrophy, and progressive supranuclear palsy show a distinct SPECT pattern in the frontal cortex, thalamus, and cerebellum. Moreover, the measurements of regional cerebral blood flow in the thalamus and cerebellum may be helpful in screening for the differential diagnosis of parkinsonian syndrome.
Noriyuki Kimura; Syojirou Hanaki; Teruaki Masuda; Takuya Hanaoka; Yusuke Hazama; Toshio Okazaki; Ryuki Arakawa; Toshihide Kumamoto
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Publication Detail:
Type:  Controlled Clinical Trial; Journal Article     Date:  2011-08-09
Journal Detail:
Title:  Movement disorders : official journal of the Movement Disorder Society     Volume:  26     ISSN:  1531-8257     ISO Abbreviation:  Mov. Disord.     Publication Date:  2011 Dec 
Date Detail:
Created Date:  2011-12-15     Completed Date:  2012-02-28     Revised Date:  2012-08-24    
Medline Journal Info:
Nlm Unique ID:  8610688     Medline TA:  Mov Disord     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2530-7     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Movement Disorder Society.
Department of Internal Medicine III, Faculty of Medicine, Oita University, Oita, Japan.
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MeSH Terms
Aged, 80 and over
Brain / blood supply*
Cerebellum / blood supply
Cerebrovascular Circulation
Diagnosis, Differential
Gyrus Cinguli / blood supply
Middle Aged
Multiple System Atrophy / physiopathology,  radionuclide imaging*
Parkinsonian Disorders / physiopathology,  radionuclide imaging*
Perfusion Imaging / methods*
Predictive Value of Tests
Sensitivity and Specificity
Supranuclear Palsy, Progressive / physiopathology,  radionuclide imaging*
Thalamus / blood supply
Tomography, Emission-Computed, Single-Photon / methods*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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