| Brain perfusion SPECT and EEG findings in Rett syndrome. | |
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MedLine Citation:
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PMID: 9048985 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Thirteen patients (mean age 8.4 + 5.3 years) with Rett syndrome (RS) were studied with EEG and 99mTc-HMPAO SPECT. Eleven patients had background abnormalities and 10 patients paroxysmal activity in EEG. Hypoperfusion of varying severity was detected in 11 patients, 7 patients having multiple lesions. Bifrontal hypoperfusion, observed in 6 patients, was the most distinctive finding. Hypoperfusion was observed also in other cortical regions, except for the occipital lobes. There was no correlation between severity of the background abnormality or presence of paroxysmal activity in EEG and grade of hypoperfusion. There was, however, an association between the severity of hypoperfusion and early manifestation of symptoms in patients with RS. Whether this early-onset group of patients represents a different disease entity or only reflects disease variability the basic pathology being the same, is a possibility that deserves further clarification. |
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Authors:
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R Lappalainen; K Liewendahl; K Sainio; P Nikkinen; R S Riikonen |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Acta neurologica Scandinavica Volume: 95 ISSN: 0001-6314 ISO Abbreviation: Acta Neurol. Scand. Publication Date: 1997 Jan |
Date Detail:
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Created Date: 1997-05-13 Completed Date: 1997-05-13 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0370336 Medline TA: Acta Neurol Scand Country: DENMARK |
Other Details:
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Languages: eng Pagination: 44-50 Citation Subset: IM |
Affiliation:
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Department of Child Neurology, Children's Castle Hospital, Helsinki, Finland. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Brain / blood supply*, physiopathology, radionuclide imaging* Cerebrovascular Circulation Child Child, Preschool Electroencephalography* Epilepsy / diagnosis, physiopathology Female Humans Organotechnetium Compounds / diagnostic use* Oximes / diagnostic use* Rett Syndrome / diagnosis*, physiopathology, radionuclide imaging* Severity of Illness Index Technetium Tc 99m Exametazime Tomography, Emission-Computed, Single-Photon* |
| Chemical | |
Reg. No./Substance:
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0/Organotechnetium Compounds; 0/Oximes; 100504-35-6/Technetium Tc 99m Exametazime |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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