Document Detail


Brain parenchymal damage after haematopoietic stem cell transplantation for severe sickle cell disease.
MedLine Citation:
PMID:  15877739     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Prospective magnetic resonance imaging (MRI), magnetic resonance angiography (MRA), neuropsychological testing and neurological examinations were performed to determine the long-term effect of successful haematopoietic stem cell transplantation on the neurological status of nine children with sickle cell disease. A scoring system for severity of brain parenchymal and vascular lesions was developed and applied. Neurological examinations and neuropsychometric tests were stable, but MRI and MRA studies were not. Transient changes occurred early in two patients. Persistent changes occurred in five. Parenchymal lesions occurred in zero of two patients without prior lacunae or infarcts and in all seven with prior lacunae or infarcts (P = 0.0278).
Authors:
Paul Woodard; Kathleen J Helton; Raja B Khan; Gregory A Hale; Sean Phipps; Winfred Wang; Rupert Handgretinger; John M Cunningham
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  British journal of haematology     Volume:  129     ISSN:  0007-1048     ISO Abbreviation:  Br. J. Haematol.     Publication Date:  2005 May 
Date Detail:
Created Date:  2005-05-09     Completed Date:  2005-06-14     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372544     Medline TA:  Br J Haematol     Country:  England    
Other Details:
Languages:  eng     Pagination:  550-2     Citation Subset:  IM    
Affiliation:
Department of Hematology/Oncology, St Jude Children's Research Hospital, 332 N. Lauderdale Street, Lauderdale, Memphis, TN 38105, USA. paul.woodard@stjude.org
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Anemia, Sickle Cell / complications,  psychology,  surgery*
Brain / pathology
Brain Diseases / etiology,  pathology*,  psychology
Brain Infarction / etiology,  psychology,  surgery
Child
Cognition Disorders / diagnosis,  etiology,  psychology
Follow-Up Studies
Humans
Magnetic Resonance Angiography
Magnetic Resonance Imaging
Neurologic Examination
Neuropsychological Tests
Prospective Studies
Stem Cell Transplantation* / adverse effects

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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