Document Detail

Brain parenchyma vessels and the angiotensin system.
MedLine Citation:
PMID:  10350564     Owner:  NLM     Status:  MEDLINE    
It is now recognized that the brain contains an autonomous angiotensin (AG) system, including the aminopeptidases A and N required for angiotensin metabolism. Using immunohistochemical techniques, we show that capillary pericytes and periendothelial cells of other vessels express aminopeptidase A (APA) and aminopeptidase N (APN) at their plasma membrane in adult mouse brain parenchyma. We therefore investigated the localization of angiotensin II(III), known as putative substrates for these enzymes, as well as that of their precursor angiotensin I. We report here the presence of immunoreactivity to angiotensin I and II(III) around most brain vessels. Angiotensins are present at the plasma membrane of brain parenchymal cells, presumably perivascular astrocytes which are also immunoreactive to AT1-receptor antibodies. The very close relationship between AGII(III) and their metabolizing enzymes APA and APN suggests a specific functional role for brain perivascular angiotensins.
F Alliot; J Rutin; P J Leenen; B Pessac
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Brain research     Volume:  830     ISSN:  0006-8993     ISO Abbreviation:  Brain Res.     Publication Date:  1999 May 
Date Detail:
Created Date:  1999-07-29     Completed Date:  1999-07-29     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0045503     Medline TA:  Brain Res     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  101-12     Citation Subset:  IM    
Copyright Information:
Copyright 1999 Elsevier Science B.V.
CNRS UPR 9035 and ER 1783 'Développement et Immunité du Système Nerveux Central', 15 rue de l'Ecole de Médecine, 75270, Paris cedex 06, France.
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MeSH Terms
Aminopeptidases / metabolism
Angiotensin II / metabolism,  physiology*
Antigens, CD13 / metabolism
Brain / blood supply*
Glutamyl Aminopeptidase
Metalloendopeptidases / metabolism
Mice, Inbred C57BL
Muscle, Smooth, Vascular / cytology,  metabolism
Reg. No./Substance:
11128-99-7/Angiotensin II; EC 3.4.11.-/Aminopeptidases; EC, CD13; EC Aminopeptidase; EC 3.4.24.-/Metalloendopeptidases

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