Document Detail

Brain-orientated intensive care treatment in severe neonatal asphyxia. Effects of phenobarbitone protection.
MedLine Citation:
PMID:  7073298     Owner:  NLM     Status:  MEDLINE    
The effect of applying brain-orientated neonatal intensive care for term infants with severe neonatal asphyxia was studied. Such treatment included protective phenobarbitone administration together with assisted ventilation and other measures to counteract postasphyxial cerebral oedema and any abrupt changes in blood pressure and oxygenation. The mortality rate and incidence of long-term sequelae were reduced appreciably, resulting in a 0-1 year mortality rate of 14% (previously 50%) and an incidence of neurodevelopmental handicap at 18 months of 17% (previously 50%). It is important in the management of infants with severe asphyxia at birth to avoid blood pressure fluctuations and to control neuronal epileptic activity by the use of barbiturates and early ventilator treatment.
N W Svenningsen; G Blennow; M Lindroth; P O Gäddlin; H Ahlström
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Archives of disease in childhood     Volume:  57     ISSN:  1468-2044     ISO Abbreviation:  Arch. Dis. Child.     Publication Date:  1982 Mar 
Date Detail:
Created Date:  1982-06-21     Completed Date:  1982-06-21     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0372434     Medline TA:  Arch Dis Child     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  176-83     Citation Subset:  AIM; IM    
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MeSH Terms
Asphyxia Neonatorum / therapy*
Blood Transfusion
Brain Damage, Chronic / prevention & control*,  therapy
Brain Edema / drug therapy
Critical Care*
Infant, Newborn
Intubation, Intratracheal
Phenobarbital / administration & dosage*,  blood
Respiration, Artificial
Seizures / drug therapy
Shock / therapy
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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