Document Detail

Brain oestradiol and testosterone levels in Alzheimer's disease.
MedLine Citation:
PMID:  10822138     Owner:  NLM     Status:  MEDLINE    
Epidemiological studies indicate that oestrogen improves memory and may delay the onset of Alzheimer's disease (AD) in postmenopausal women. Furthermore, evidence from experimental studies suggests beneficial effects of oestrogen on several pathogenic mechanisms implicated in AD. We have therefore measured the levels of oestradiol and testosterone in control and AD brains. The results show that in control brain, oestradiol levels are 3.5 fold higher in females than males, though testosterone levels are equivalent. In AD, oestradiol levels were not significantly increased compared to those in control brain, while testosterone levels were unaffected in AD. The results do not support the hypothesis that a lack of oestrogen is a contributory factor in AD.
S J Twist; G A Taylor; A Weddell; D R Weightman; J A Edwardson; C M Morris
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Neuroscience letters     Volume:  286     ISSN:  0304-3940     ISO Abbreviation:  Neurosci. Lett.     Publication Date:  2000 May 
Date Detail:
Created Date:  2000-07-14     Completed Date:  2000-07-14     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7600130     Medline TA:  Neurosci Lett     Country:  IRELAND    
Other Details:
Languages:  eng     Pagination:  1-4     Citation Subset:  IM    
MRC Neurochemical Pathology Unit, Institute for the Health of the Elderly, Newcastle General Hospital, Westgate Road, University of Newcastle, NE4 6BE, Newcastle upon Tyne, UK.
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MeSH Terms
Alzheimer Disease / drug therapy,  metabolism*,  physiopathology*
Brain / metabolism*,  pathology,  physiopathology*
Estradiol / metabolism*
Frontal Lobe / metabolism,  physiopathology
Sex Factors
Temporal Lobe / metabolism,  physiopathology
Testosterone / metabolism*
Reg. No./Substance:
50-28-2/Estradiol; 58-22-0/Testosterone

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