Document Detail


Brain norepinephrine and metabolites after treadmill training and wheel running in rats.
MedLine Citation:
PMID:  8775155     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Regional changes in concentrations of brain norepinephrine [NE] and its metabolites after chronic exercise have not been described for exercise protocols not confounded by other stressors. We examined levels of [NE], 3-methoxy-4-hydroxyphenylglycol [MHPG], and 3,4-dihydroxyphenylglycol [DHPG] in the frontal cortex, hippocampus, pons-medulla, and spinal cord after 8 wk of exercise. Male Sprague-Dawley rats (N = 36) were randomly assigned to three conditions: 1) 24-h access to activity wheel running (WR), 2) treadmill running (TR) at 0 degrees incline for 1 h.d-1 at 25-30 m.min-1, or 3) a sedentary control group (C). Levels (nmol.g-1) of [NE], [MHPG], and [DHPG] were assayed by high performance liquid chromatography with electrochemical detection. Planned contrasts (P < 0.05) indicated that exercise training increased succinate dehydrogenase activity (mmol cytochrome C reduced.min-1.g-1 wet weight) in soleus muscle for TR compared with WR or C. [NE] was higher in the pons-medulla and spinal cord for both TR and WR compared with C. [DHPG] was higher in the pons-medulla for TR compared with C, and [MHPG] was higher in the frontal cortex and in the hippocampus for TR compared with C. Our results suggest that treadmill exercise training is accompanied by brain noradrenergic adaptations consistent with increased metabolism of NE in areas containing NE cell bodies and ascending terminals, whereas treadmill running and wheel running are accompanied by increases in levels of NE in the areas of NE cell bodies and the spinal cord, independently of an exercise training effect.
Authors:
A L Dunn; T G Reigle; S D Youngstedt; R B Armstrong; R K Dishman
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Medicine and science in sports and exercise     Volume:  28     ISSN:  0195-9131     ISO Abbreviation:  Med Sci Sports Exerc     Publication Date:  1996 Feb 
Date Detail:
Created Date:  1996-12-04     Completed Date:  1996-12-04     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  8005433     Medline TA:  Med Sci Sports Exerc     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  204-9     Citation Subset:  IM; S    
Affiliation:
Department of Exercise Science, University of Georgia, Athens 30602-3654, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Brain Chemistry*
Frontal Lobe / chemistry
Hippocampus / chemistry
Male
Norepinephrine / analysis*
Physical Conditioning, Animal*
Pons / chemistry
Rats
Rats, Sprague-Dawley
Spinal Cord / chemistry
Chemical
Reg. No./Substance:
51-41-2/Norepinephrine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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