Document Detail

Brain neurotransmitter abnormalities in neuronal intranuclear inclusion body disorder.
MedLine Citation:
PMID:  2408557     Owner:  NLM     Status:  MEDLINE    
Biochemical markers for the major neurotransmitter systems were measured in the brain of a patient who died with neuronal intranuclear inclusion disease. A severe nigrostriatal dopamine deficiency constitutes the basis for the parkinsonian features in the patient. A marked loss of brain norepinephrine and serotonin was found in the basal ganglia and hypothalamus. Brain amino acid (gamma-aminobutyric acid and glutamate) and cholinergic (choline acetyltransferase activity) systems were either normal or less severely affected.
S J Kish; J J Gilbert; L J Chang; L Mirchandani; K Shannak; O Hornykiewicz
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Annals of neurology     Volume:  17     ISSN:  0364-5134     ISO Abbreviation:  Ann. Neurol.     Publication Date:  1985 Apr 
Date Detail:
Created Date:  1985-07-02     Completed Date:  1985-07-02     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7707449     Medline TA:  Ann Neurol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  405-7     Citation Subset:  IM    
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MeSH Terms
Brain / pathology
Brain Diseases / metabolism*,  pathology
Dopamine / analysis
Homovanillic Acid / analysis
Hydroxyindoleacetic Acid / analysis
Inclusion Bodies / metabolism*,  pathology
Neurons / metabolism*,  pathology
Neurotransmitter Agents / analysis*
Norepinephrine / analysis
Serotonin / analysis
gamma-Aminobutyric Acid / analysis
Reg. No./Substance:
0/Neurotransmitter Agents; 306-08-1/Homovanillic Acid; 50-67-9/Serotonin; 51-41-2/Norepinephrine; 54-16-0/Hydroxyindoleacetic Acid; 56-12-2/gamma-Aminobutyric Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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