| Brain natriuretic peptide variations are linked to volume status in hemodialysis patients. | |
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MedLine Citation:
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PMID: 19049708 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIMS: To evaluate the usefulness of monthly brain natriuretic peptide (BNP) dosage in assessing dry weight in hemodialysis patients. PATIENTS AND METHODS: Over a 2-year period, we performed in 46 hemodialysis patients monthly BNP level measurements, and adapted dry weight following the determination of variations in BNP concentrations for each month during the study period. Then we tested our approach by looking for a statistical relation between monthly alterations in BNP levels and monthly variations in the patients' weight, blood pressure, hemoglobinemia and albuminemia which are in themselves related to fluid status variations. RESULTS: Monthly BNP level variations were found to be positively correlated with monthly end-dialysis weight alterations (r = +0.24, p < 0.001), with monthly systolic and diastolic blood pressure variations before dialysis (r = +0.09, p < 0.001; r = +0.24, p < 0.001), and with systolic and diastolic blood pressure changes after dialysis (r = +0.09, p = 0.001; r = +0.25, p < 0.001). Moreover, monthly BNP level variations were negatively correlated with monthly hemoglobinemia changes (r = -0.17, p = 0.004) and with monthly albuminemia alterations (r = -0.14, p = 0.001). CONCLUSION: In a non-selected population of hemodialysis patients it was found that monthly BNP level variations were positively correlated with monthly volume status alterations as evaluated by clinical and biological criteria. BNP appears to be a useful tool for dry weight assessment despite the absence of a standardized cut-off point for BNP levels in hemodialysis patients. |
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Authors:
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S Roueff; E Martin; M-L Chauffert; I Poli; K Kihal; F Yazbeck; A Abbassi; M Saint-Georges |
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Publication Detail:
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Type: Clinical Trial; Comparative Study; Journal Article |
Journal Detail:
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Title: Clinical nephrology Volume: 70 ISSN: 0301-0430 ISO Abbreviation: Clin. Nephrol. Publication Date: 2008 Dec |
Date Detail:
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Created Date: 2008-12-03 Completed Date: 2009-03-24 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0364441 Medline TA: Clin Nephrol Country: Germany |
Other Details:
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Languages: eng Pagination: 508-13 Citation Subset: IM |
Affiliation:
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Centre de Traitement de l'Insuffisance Rénale Chronique, Hôpital National de Saint Maurice, St. Maurice, France. s.roueff@hopital-saint-maurice.fr |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Biological Markers
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blood Blood Pressure / physiology Blood Volume / physiology* Body Fluids / physiology* Body Weight / physiology* Female Fluorescence Polarization Immunoassay Follow-Up Studies Humans Kidney Failure, Chronic / blood*, physiopathology, therapy Male Middle Aged Natriuretic Peptide, Brain / blood* Renal Dialysis / methods* Retrospective Studies Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 114471-18-0/Natriuretic Peptide, Brain |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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