| Brain natriuretic peptide response is heterogeneous during beta-blocker therapy for congestive heart failure. | |
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MedLine Citation:
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PMID: 15309697 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Plasma brain natriuretic peptide (BNP) levels are useful marker to guide medical treatment in patients with congestive heart failure (CHF). We tested the hypothesis that the plasma BNP concentration would be a useful marker of beta-blocker therapy for CHF. METHODS AND RESULTS: Eighty-four patients with New York Heart Association class II-IV CHF and a left ventricular ejection fraction (LVEF) <40% were treated with beta-blockers, including metoprolol and carvedilol, for at least 16 weeks. End-diastolic and end-systolic dimensions decreased, and radionuclide LVEF increased 4 weeks after introduction of beta-blockers (early phase). LV end-diastolic and end-systolic dimensions both decreased, and LVEF increased 16 to 48 weeks after the therapy (late phase). However, the BNP concentration did not change during the observation period. Overall LV function improved in all 4 subgroups divided according to the baseline BNP levels. CONCLUSIONS: Plasma BNP concentration is not a sensitive marker of successful beta-blocker therapy for CHF. |
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Authors:
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Akihiro Yoshizawa; Tsutomu Yoshikawa; Iwao Nakamura; Toru Satoh; Kazunori Moritani; Masahiro Suzuki; Akiyasu Baba; Shiro Iwanaga; Hideo Mitamura; Satoshi Ogawa |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Journal of cardiac failure Volume: 10 ISSN: 1071-9164 ISO Abbreviation: J. Card. Fail. Publication Date: 2004 Aug |
Date Detail:
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Created Date: 2004-08-13 Completed Date: 2005-08-19 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9442138 Medline TA: J Card Fail Country: United States |
Other Details:
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Languages: eng Pagination: 310-5 Citation Subset: IM |
Affiliation:
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Cardiology Division, Department of Medicine, Keio University School of Medicine, Tokyo, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adrenergic beta-Antagonists
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administration & dosage,
therapeutic use* Adult Aged Aged, 80 and over Biological Markers / blood Blood Pressure / drug effects Carbazoles / administration & dosage, therapeutic use Dose-Response Relationship, Drug Female Follow-Up Studies Heart Failure / drug therapy* Humans Male Metoprolol / administration & dosage, therapeutic use Middle Aged Myocardial Contraction / drug effects Natriuretic Peptide, Brain / blood, drug effects* Propanolamines / administration & dosage, therapeutic use Stroke Volume / drug effects Time Factors Treatment Outcome Ventricular Function, Left / drug effects |
| Chemical | |
Reg. No./Substance:
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0/Adrenergic beta-Antagonists; 0/Biological Markers; 0/Carbazoles; 0/Propanolamines; 114471-18-0/Natriuretic Peptide, Brain; 37350-58-6/Metoprolol; 72956-09-3/carvedilol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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