| Brain natriuretic peptide: a potential marker for mortality in septic shock. | |
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MedLine Citation:
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PMID: 15325595 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Brain natriuretic peptide (BNP) is a diagnostic marker for left ventricular dysfunction. Sepsis and septic shock are increasing in incidence and mortality. Myocardial dysfunction frequently accompanies severe sepsis and septic shock. Although previously described as a preterminal event, ventricular dysfunction with reduced ejection fraction and biventricular dilatation is present in most patients with severe sepsis and septic shock. In survivors, this depression in cardiac function is reversible over the course of seven to ten days. Even though some prognostic factors have been identified in patients with sepsis-induced myocardial dysfunction, their measurement often includes costly and cumbersome techniques. Thus, there is a need for an inexpensive, simple, rapid and readily available marker to predict mortality in septic shock. At present, a relationship between BNP with myocardial dysfunction in septic shock has not been evaluated. However, growing evidence supports the hypothesis that BNP could be an early predictor of mortality in septic shock. If proven, the hypothesis would have important clinical and public health implications. |
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Authors:
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Jose R Castillo; Axel Zagler; Rodolfo Carrillo-Jimenez; Charles H Hennekens |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases Volume: 8 ISSN: 1201-9712 ISO Abbreviation: Int. J. Infect. Dis. Publication Date: 2004 Sep |
Date Detail:
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Created Date: 2004-08-24 Completed Date: 2004-10-28 Revised Date: 2005-11-16 |
Medline Journal Info:
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Nlm Unique ID: 9610933 Medline TA: Int J Infect Dis Country: Canada |
Other Details:
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Languages: eng Pagination: 271-4 Citation Subset: IM |
Affiliation:
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Department of Medicine, Mount Sinai Medical Center-Miami Heart Institute, Miami, FL 33140, USA. jrcastillo_md@yahoo.com |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Biological Markers
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blood* Humans Natriuretic Peptide, Brain / blood* Shock, Septic / mortality* Ventricular Dysfunction, Left / diagnosis* |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 114471-18-0/Natriuretic Peptide, Brain |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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