Document Detail

Brain natriuretic peptide levels and cardiac functional capacity in patients with dyspnea and isolated diastolic dysfunction.
MedLine Citation:
PMID:  17379983     Owner:  NLM     Status:  MEDLINE    
Diastolic heart failure affects approximately 40%-50% of patients presenting with signs and symptoms of heart failure. The aim of this study was to investigate the relationship between brain natriuretic peptide (BNP) levels and functional capacity in patients admitted with dyspnea and diagnosed with isolated diastolic dysfunction. Fifty-four patients (mean age, 57.4 +/- 8.5 years) with class-2 dyspnea with isolated diastolic dysfunction were enrolled. Serum levels of BNP were measured, and peak oxygen consumption (peak VO(2)), anaerobic threshold (AT), and metabolic equivalent (MET) values were determined with a cardiopulmonary exercise test (CPET). There was a negative correlation between BNP levels and exercise duration (P < 0.05, r = -0.304), AT (P < 0.05, r = -0.380), and number of MET (P < 0.05, r = -0.322) determined by CPET. When patients were divided into 2 groups according to BNP levels; BNP < or = 50 pg/mL (n = 40) versus BNP > 50 pg/mL (n = 14) and analyzed, those with BNP levels > 50 pg/mL had lower peak VO(2) (P = 0.05) and anaerobic threshold (P = 0.01) compared with patients with BNP < or = 50 pg/mL. The results suggest that BNP levels provide an indication about the functional capacity determined by CPET in patients admitted with dyspnea and isolated diastolic dysfunction.
Serpil Eroglu; Aylin Yildirir; Huseyin Bozbas; Alp Aydinalp; Gaye Ulubay; Olcay Eldem; Vahide Simsek; Bulent Ozin; Haldun Muderrisoglu
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International heart journal     Volume:  48     ISSN:  1349-2365     ISO Abbreviation:  -     Publication Date:  2007 Jan 
Date Detail:
Created Date:  2007-03-23     Completed Date:  2007-09-27     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101244240     Medline TA:  Int Heart J     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  97-106     Citation Subset:  IM    
Department of Cardiology, Faculty of Medicine, Baskent University, Ankara, Turkey.
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MeSH Terms
Anaerobic Threshold / physiology
Biological Markers / blood
Disease Progression
Dyspnea* / blood,  etiology,  physiopathology
Exercise Test
Fluorescent Antibody Technique
Follow-Up Studies
Heart Ventricles / physiopathology,  ultrasonography
Middle Aged
Myocardial Contraction / physiology*
Natriuretic Peptide, Brain / blood*
Oxygen Consumption
Retrospective Studies
Severity of Illness Index
Ventricular Dysfunction, Left* / blood,  complications,  physiopathology
Reg. No./Substance:
0/Biological Markers; 114471-18-0/Natriuretic Peptide, Brain

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