| Brain natriuretic peptide kinetics during dynamic exercise in patients with chronic heart failure. | |
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MedLine Citation:
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PMID: 15159038 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: The kinetics of brain natriuretic peptide (BNP) secretion in chronic heart failure (CHF) during dynamic exercise have been the subject of controversial debate. The present study was therefore aimed to further clarify whether marked changes in BNP levels occur during and directly after vigorous exercise in CHF patients. METHODS: We prospectively studied 37 patients with CHF (60+/-10 years, LVEF 26+/-6%) and 20 healthy controls (58+/-11 years, LVEF 60+/-3%). Standardized exercise testing was performed in all CHF patients and controls. Venous blood samples for measurement of BNP were obtained prior to symptom-limited exercise, at peak exercise and at 1 and 5 min of recovery time. RESULTS: BNP concentrations were significantly higher in CHF compared to controls at rest, peak exercise and at 1 and 5 min of recovery. BNP levels did not change significantly during exercise in the control group. In CHF patients, BNP levels showed no marked difference at rest (428+/-421 pg/ml), peak exercise (507+/-450 pg/ml, n.s.), 1 min (560+/-460 pg/ml, n.s.) and 5 min recovery (526+/-424 pg/ml, n.s.). Strikingly, 6 of 37 CHF patients (16%) showed a decrease in BNP at exercise compared to rest but none of the controls. CONCLUSIONS: BNP levels in CHF patients and healthy controls are not significantly altered by vigorous exercise. In contrast to controls, 16% of CHF patients showed a decrease in BNP levels at exercise. In CHF, BNP levels were inversely correlated with peak VO(2), VO(2)-AT and LVEF. |
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Authors:
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Stefan Krüger; Jürgen Graf; Marc W Merx; Tina Stickel; Dagmar Kunz; Peter Hanrath; Uwe Janssens |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: International journal of cardiology Volume: 95 ISSN: 0167-5273 ISO Abbreviation: Int. J. Cardiol. Publication Date: 2004 May |
Date Detail:
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Created Date: 2004-05-25 Completed Date: 2004-11-08 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8200291 Medline TA: Int J Cardiol Country: Ireland |
Other Details:
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Languages: eng Pagination: 49-54 Citation Subset: IM |
Affiliation:
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Medical Clinic I, University Hospital, University of Technology, Aachen, Germany. skrueger@ukaachen.de |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Biological Markers / blood Cardiomyopathy, Dilated / complications, metabolism, physiopathology Chronic Disease Coronary Artery Disease / complications, metabolism, physiopathology Exercise / physiology* Exercise Test Female Follow-Up Studies Heart Failure / etiology, metabolism*, mortality, physiopathology* Humans Male Middle Aged Natriuretic Peptide, Brain / metabolism* Oxygen Consumption / physiology Prospective Studies Statistics as Topic Stroke Volume / physiology Survival Analysis |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 114471-18-0/Natriuretic Peptide, Brain |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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