Document Detail

Brain natriuretic peptide in cardiac surgery--influence of aprotinin.
MedLine Citation:
PMID:  18625528     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: This study was designed to examine plasma concentrations of BNP and its correlations to the perioperative course in patients' cardiopulmonary bypass (CPB). METHODS: Sixty-five patients with coronary artery disease (CAD) undergoing CPB were examined. Pre, intra and postoperative BNP values and hemodynamic parameters were measured. RESULTS: The BNP peak correlated neither with any hemodynamic parameters, with the duration of aortic cross-clamping (AXCL), of the operation or with CBP-time, nor with the use of catecholamines. BNP values were significantly higher with the perioperative use of aprotinin. CONCLUSION: These results confirm that the metabolism and biological activity of BNP may differ following CPB. An additional reason for increased postoperative BNP values might be the use of aprotinin.
Dorothee H L Bail; Gerhard Ziemer
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Publication Detail:
Type:  Letter; Research Support, Non-U.S. Gov't     Date:  2008-07-14
Journal Detail:
Title:  International journal of cardiology     Volume:  136     ISSN:  1874-1754     ISO Abbreviation:  Int. J. Cardiol.     Publication Date:  2009 Aug 
Date Detail:
Created Date:  2009-07-27     Completed Date:  2009-10-14     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8200291     Medline TA:  Int J Cardiol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  227-8     Citation Subset:  IM    
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MeSH Terms
Aprotinin / administration & dosage*
Cardiac Surgical Procedures*
Cardiopulmonary Bypass*
Hemostatics / administration & dosage*
Middle Aged
Natriuretic Peptide, Brain / blood*
Reg. No./Substance:
0/Hemostatics; 114471-18-0/Natriuretic Peptide, Brain; 9087-70-1/Aprotinin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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