| Brain natriuretic peptide detects cardiac abnormalities in mass screening. | |
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MedLine Citation:
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PMID: 17373960 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Plasma brain natriuretic peptide (BNP) is elevated in asymptomatic patients with various cardiac abnormalities. We tested the hypothesis that measuring BNP is useful for detecting asymptomatic patients with cardiac abnormalities who are not identified by conventional health check-up programmes. MATERIALS AND METHODS: From 2001 to 2002, 6189 subjects (women 34.0%; mean age 56.6 years) underwent multiphasic health check-ups in our hospital, of which 4818 without cardiac abnormalities as revealed by the health check-up were enrolled in the present study. Their plasma concentrations of BNP were measured. RESULTS: Plasma concentrations of BNP were higher than the normal reference upper limit of our hospital (21.3 pg mL(-1)) in 925 of the 4818 subjects. Echocardiography was performed in 471 subjects who were randomly selected from the 925 subjects with elevated BNP. Abnormal findings were detected in 174 subjects, comprising valvular heart disease in 83, systolic dysfunction in 10, diastolic dysfunction in 54, left ventricular hypertrophy in 41, left ventricular enlargement in 11, left atrial enlargement in 13 and paroxysmal atrial fibrillation in 3. CONCLUSIONS: Since BNP measurement identifies additional subjects with cardiac abnormalities, it is useful for detecting asymptomatic cardiac abnormalities among apparently healthy subjects, and is suitable for use in high-quality mass screening. |
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Authors:
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H Takase; T Toriyama; T Sugiura; A Takahashi; M Sugiyama; M Ohashi; R Ueda; Y Dohi |
Publication Detail:
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Type: Evaluation Studies; Journal Article |
Journal Detail:
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Title: European journal of clinical investigation Volume: 37 ISSN: 0014-2972 ISO Abbreviation: Eur. J. Clin. Invest. Publication Date: 2007 Apr |
Date Detail:
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Created Date: 2007-03-21 Completed Date: 2007-08-15 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0245331 Medline TA: Eur J Clin Invest Country: England |
Other Details:
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Languages: eng Pagination: 257-62 Citation Subset: IM |
Affiliation:
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Department of Internal Medicine, Enshu General Hospital, 144-6 Tokiwa-cho, Hamamatsu, Shizuoka 430-0917, Japan. h-takase@ken.ja-shizuoka.or.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aged, 80 and over Atrial Natriuretic Factor / blood* Echocardiography / methods Female Heart Diseases / diagnosis* Humans Male Mass Screening / standards* Middle Aged Natriuretic Peptide, Brain / blood* Prospective Studies |
| Chemical | |
Reg. No./Substance:
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114471-18-0/Natriuretic Peptide, Brain; 85637-73-6/Atrial Natriuretic Factor |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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