Document Detail

Brain natriuretic peptide can be a useful biochemical marker for myocarditis in patients with Kawasaki disease.
MedLine Citation:
PMID:  12018720     Owner:  NLM     Status:  MEDLINE    
RESULTS: The mean concentration of brain natriuretic peptide in the plasma was 73.2 +/- 107.7 (mean +/- SD) pg/ml in the acute phase, and 7.9 +/- 7.5 pg/ml in the convalescent phase. We checked the electrocardiograms to find abnormal Q waves, elevation or depression of the ST segments, change in the pattern of the QRS complexes, and flattening or inversion of the T wave, all believed to be markers of myocarditis in Kawasaki disease. Those in whom the concentrations were greater than 50 pg/ml in the acute phase showed abnormal electrocardiograms more frequently than did those in whom the values were less than 50 pg/ml (21/29 vs 3/40, p < 0.0001 odds ratio 32.4). Amplitudes of the T wave in standard limb leads were measured both in the acute and convalescent phases, and the differences calculated. We regarded the sum total of these differences as representing "flattening T wave", and we named this variable as the total suppressed T wave voltage. We examined the correlation between the variable and the levels of brain natriuretic peptide in the plasma during the acute phase, demonstrating a significant correlation (r = 0.500, p < 0.0001). We conclude, therefore, that the concentration of brain natriuretic peptide measured in the plasma can be a useful biochemical marker for the myocarditis of Kawasaki disease. When the titer is over 50 pg/ml, the patient probably has an abnormal electrocardiogram and is most likely to have myocarditis.
Takashi Kawamura; Masakuni Wago
Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Cardiology in the young     Volume:  12     ISSN:  1047-9511     ISO Abbreviation:  Cardiol Young     Publication Date:  2002 Mar 
Date Detail:
Created Date:  2002-05-20     Completed Date:  2002-11-20     Revised Date:  2014-07-28    
Medline Journal Info:
Nlm Unique ID:  9200019     Medline TA:  Cardiol Young     Country:  England    
Other Details:
Languages:  eng     Pagination:  153-8     Citation Subset:  IM    
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MeSH Terms
Biological Markers / analysis
Chi-Square Distribution
Child, Preschool
Cohort Studies
Echocardiography / methods
Electrocardiography / methods
Mucocutaneous Lymph Node Syndrome / complications*,  diagnosis
Myocarditis / blood,  diagnosis*,  etiology
Natriuretic Peptide, Brain / analysis,  blood*
Retrospective Studies
Sensitivity and Specificity
Severity of Illness Index
Reg. No./Substance:
0/Biological Markers; 114471-18-0/Natriuretic Peptide, Brain

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