Document Detail

Brain natriuretic peptide and acute coronary syndrome.
MedLine Citation:
PMID:  15827538     Owner:  NLM     Status:  MEDLINE    
The natriuretic peptide system (atrial natriuretic peptide, brain natriuretic peptide, BNP, and C natriuretic peptide) is an important marker of cardiac failure. These peptides are synthesized in atrial or ventricular myocytes in response to wall tension. In several studies the correlation between high BNP levels and mortality, in patients with acute coronary syndrome and heart failure, has been demonstrated. On the other hand, plasma levels of BNP could be considered as independent predictors of mortality in patients with heart failure. BNP could be used, for instance, as an early diagnostic marker for the differential diagnosis between cardiogenic and non cardiogenic dyspnea. In the Emergency Department its use will be important in the diagnosis of thoracic pain origin since it may help in the diagnostic and therapeutic course of this patient and to define the modality of hospitalization. Moreover, it can be used as a marker of heart failure severity and as an important negative prognostic factor. Some studies have confirmed that plasma BNP reflects the degree of left ventricular dysfunction and the prognostic significance after acute myocardial infarction and chronic heart failure.
M Mazzone; P Forte; G Portale; F Mancini; S Ursella; M La Sala; A Testa; M Covino; G Pignataro; N Gentiloni Silveri
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Minerva medica     Volume:  96     ISSN:  0026-4806     ISO Abbreviation:  Minerva Med.     Publication Date:  2005 Feb 
Date Detail:
Created Date:  2005-04-13     Completed Date:  2006-07-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0400732     Medline TA:  Minerva Med     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  11-8     Citation Subset:  IM    
Department of Emergency and Admission A. Gemelli, University Hospital, UCSC, Rome, Italy.
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MeSH Terms
Angina, Unstable / blood*,  diagnosis,  mortality
Atrial Natriuretic Factor / blood
Biological Markers / blood*
Diagnosis, Differential
Myocardial Infarction / blood*,  diagnosis,  mortality
Natriuretic Peptide, Brain / blood*
Protein Precursors / blood
Ventricular Dysfunction, Left / blood*,  diagnosis,  mortality
Reg. No./Substance:
0/Biological Markers; 0/Protein Precursors; 114471-18-0/Natriuretic Peptide, Brain; 85637-73-6/Atrial Natriuretic Factor

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