Document Detail

Brain natriuretic peptide (BNP) produced by the human chorioamnion may mediate pregnancy myometrial quiescence.
MedLine Citation:
PMID:  19144889     Owner:  NLM     Status:  MEDLINE    
We aim to demonstrate that Brain Natriuretic Peptide (BNP) is synthesized and released from the fetal membranes and mediates pregnancy myometrial quiescence. Myometrium and fetal membranes (FM) were obtained from term and preterm pregnancies at the time of cesarean section, either in labor or not in labor. BNP was measured in term and preterm FM, in culture cells, and conditioned media. We found BNP (but not ANP or CNP) inhibited contractions of preterm, but not term, human myometrium. BNP (both protein and mRNA) was detected in all tissues, conditioned media and cultured cells. BNP was higher in samples from preterm women not in labor compared to those at term not in labor. BNP concentrations were significantly reduced in women in spontaneous preterm labor. We conclude that locally produced BNP may be involved in generating myometrial quiescence during pregnancy. Further, a premature decrease of BNP production may cause preterm labor.
Jorge A Carvajal; Ana M Delpiano; Mauricio A Cuello; Jose A Poblete; Paola C Casanello; Luis A Sobrevia; Carl P Weiner
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Reproductive sciences (Thousand Oaks, Calif.)     Volume:  16     ISSN:  1933-7205     ISO Abbreviation:  Reprod Sci     Publication Date:  2009 Jan 
Date Detail:
Created Date:  2009-01-15     Completed Date:  2009-03-27     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101291249     Medline TA:  Reprod Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  32-42     Citation Subset:  IM    
Unidad de Medicina Materno Fetal, Departamento de Obstetricia y Ginecología, Pontificia Universidad Catolica de Chile, Santiago, Chile.
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MeSH Terms
Chorioallantoic Membrane / metabolism*
Labor, Obstetric / metabolism
Myometrium / drug effects,  metabolism*
Natriuretic Peptide, Brain / biosynthesis*,  genetics,  pharmacology*
RNA, Messenger / biosynthesis,  genetics
Reverse Transcriptase Polymerase Chain Reaction
Uterine Contraction / drug effects*,  physiology
Young Adult
Reg. No./Substance:
0/RNA, Messenger; 114471-18-0/Natriuretic Peptide, Brain

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