| Brain natriuretic peptide (BNP) produced by the human chorioamnion may mediate pregnancy myometrial quiescence. | |
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MedLine Citation:
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PMID: 19144889 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We aim to demonstrate that Brain Natriuretic Peptide (BNP) is synthesized and released from the fetal membranes and mediates pregnancy myometrial quiescence. Myometrium and fetal membranes (FM) were obtained from term and preterm pregnancies at the time of cesarean section, either in labor or not in labor. BNP was measured in term and preterm FM, in culture cells, and conditioned media. We found BNP (but not ANP or CNP) inhibited contractions of preterm, but not term, human myometrium. BNP (both protein and mRNA) was detected in all tissues, conditioned media and cultured cells. BNP was higher in samples from preterm women not in labor compared to those at term not in labor. BNP concentrations were significantly reduced in women in spontaneous preterm labor. We conclude that locally produced BNP may be involved in generating myometrial quiescence during pregnancy. Further, a premature decrease of BNP production may cause preterm labor. |
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Authors:
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Jorge A Carvajal; Ana M Delpiano; Mauricio A Cuello; Jose A Poblete; Paola C Casanello; Luis A Sobrevia; Carl P Weiner |
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Publication Detail:
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Type: In Vitro; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Reproductive sciences (Thousand Oaks, Calif.) Volume: 16 ISSN: 1933-7205 ISO Abbreviation: Reprod Sci Publication Date: 2009 Jan |
Date Detail:
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Created Date: 2009-01-15 Completed Date: 2009-03-27 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101291249 Medline TA: Reprod Sci Country: United States |
Other Details:
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Languages: eng Pagination: 32-42 Citation Subset: IM |
Affiliation:
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Unidad de Medicina Materno Fetal, Departamento de Obstetricia y Ginecología, Pontificia Universidad Catolica de Chile, Santiago, Chile. jcarva@med.puc.cl |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Biopsy Chorioallantoic Membrane / metabolism* Female Humans Labor, Obstetric / metabolism Myometrium / drug effects, metabolism* Natriuretic Peptide, Brain / biosynthesis*, genetics, pharmacology* Pregnancy RNA, Messenger / biosynthesis, genetics Reverse Transcriptase Polymerase Chain Reaction Uterine Contraction / drug effects*, physiology Young Adult |
| Chemical | |
Reg. No./Substance:
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0/RNA, Messenger; 114471-18-0/Natriuretic Peptide, Brain |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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