| Brain natriuretic peptide (BNP) level is closely related to the extent of left ventricular sympathetic overactivity in chronic ischemic heart failure. | |
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MedLine Citation:
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PMID: 19293536 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: Both brain natriuretic peptide (BNP) and cardiac sympathetic activity are useful surrogate markers of congestive heart failure. BNP is known to be secreted in response to sympathetic tone. This study examined the relationship between the cardiac sympathetic system and BNP. PATIENTS AND METHODS: Sixty patients with chronic ischemic heart failure (mean age,72 years-old; 46 males and 14 females) who had undergone cardiac catheterization and were classified as NYHA II underwent resting (99m)Tc-sestamibi quantitative gated imaging (MIBI) and (123)I-metaiodobenzylguanidine imaging (MIBG). MIBI was used to obtain left ventricular (LV) dimension. MIBG was used to obtain the washout rate and the H/M ratios as well as the extent of LV washout rate abnormality (RSNA), which was defined as the number of regions with a regional washout rate of more than mean+2SD of 15 normal subjects on a two-dimensional polar map divided into 20 regions. Blood samples were obtained to measure neurohormones such as BNP, renin activity, noradrenaline, and angiotensin II. RESULTS: Simple linear regression analysis showed that BNP had significant correlations to age, LVEF, LV end diastolic volume, LV end systolic volume, RSNA, global washout rate, myocardial ischemia, and LV end diastolic pressure. Among them, multiple linear regression analysis showed that only RSNA (partial regression coefficient =0.618, p<0.002) had a significant positive correlation with BNP. CONCLUSION: This study suggested that the extent of cardiac sympathetic overactivity in the LV could enhance BNP release. |
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Authors:
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Kazuyuki Sakata; Kei Iida; Nao Mochiduki; Yoshihiro Nakaya |
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Publication Detail:
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Type: Comparative Study; Journal Article Date: 2009-03-16 |
Journal Detail:
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Title: Internal medicine (Tokyo, Japan) Volume: 48 ISSN: 1349-7235 ISO Abbreviation: Intern. Med. Publication Date: 2009 |
Date Detail:
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Created Date: 2009-03-18 Completed Date: 2009-08-25 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9204241 Medline TA: Intern Med Country: Japan |
Other Details:
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Languages: eng Pagination: 393-400 Citation Subset: IM |
Affiliation:
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Division of Cardiology, Shizuoka Cancer Center Hospital, Shizuoka. k.sakata@scchr.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Aged, 80 and over Cardiac-Gated Single-Photon Emission Computer-Assisted Tomography / methods Chemiluminescent Measurements Chromatography, High Pressure Liquid Disease Progression Electrocardiography Epinephrine / blood Female Follow-Up Studies Heart Catheterization Heart Failure / blood*, etiology, physiopathology Heart Ventricles / innervation*, physiopathology, radionuclide imaging Humans Male Middle Aged Myocardial Infarction / complications*, physiopathology Natriuretic Peptide, Brain / blood* Norepinephrine / blood Radioimmunoassay Renin / blood Severity of Illness Index Stroke Volume / physiology Sympathetic Nervous System / metabolism, physiopathology* Ventricular Dysfunction, Left / blood, complications, physiopathology* |
| Chemical | |
Reg. No./Substance:
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114471-18-0/Natriuretic Peptide, Brain; 51-41-2/Norepinephrine; 51-43-4/Epinephrine; EC 3.4.23.15/Renin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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