Document Detail

Brain monoamine metabolism is altered in rats following spontaneous, long-distance running.
MedLine Citation:
PMID:  3111175     Owner:  NLM     Status:  MEDLINE    
Brain monoamine metabolism in rats was studied during spontaneous, long-term running in a microprocessor-controlled wheel cage. Immediately after heavy spontaneous exercise, DOPA accumulation was decreased in dopamine-rich brain regions such as the limbic forebrain and corpus striatum, indicating a decreased rate of synthesis of dopamine in brain. In contrast, DOPA accumulation was increased in the noradrenaline-predominated region of the brain stem, indicating an increased synthesis of noradrenaline in this region. Alterations in brain monoamine metabolism were normalized in exercising animals analysed 24 h after the last running period. Changes in brain monoamine metabolism may be involved in the mechanisms underlying the clinically observed psychological effects of physical exercise.
M Elam; T H Svensson; P Thorén
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Acta physiologica Scandinavica     Volume:  130     ISSN:  0001-6772     ISO Abbreviation:  Acta Physiol. Scand.     Publication Date:  1987 Jun 
Date Detail:
Created Date:  1987-08-11     Completed Date:  1987-08-11     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0370362     Medline TA:  Acta Physiol Scand     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  313-6     Citation Subset:  IM    
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MeSH Terms
Brain / metabolism*
Catecholamines / metabolism*
Dihydroxyphenylalanine / metabolism
Dopamine / metabolism
Norepinephrine / metabolism
Physical Exertion*
Rats, Inbred WKY
Serotonin / metabolism
Time Factors
Reg. No./Substance:
0/Catecholamines; 50-67-9/Serotonin; 51-41-2/Norepinephrine; 63-84-3/Dihydroxyphenylalanine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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