Document Detail


Brain metastasis of choriocarcinoma.
MedLine Citation:
PMID:  7202257     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Twenty-four patients with histologically verified brain metastasis of choriocarcinoma were analyzed regarding autopsy and operative findings, signs and symptoms, diagnosis, method of treatment, and prognosis. The autopsy incidence of brain metastasis was 66.7% in patients with choriocarcinoma, and the predominance of single brain lesions was confirmed. Most of the metastatic lesions were hemorrhagic. The hemorrhages were intratumoral, peritumoral, and/or subarachnoid. These findings were well correlated with the findings on computed tomographic (CT) scans and the acute onset with rapid progression of symptoms. The history of molar pregnancy, measurements of urinary chorionic gonadotropin, and findings on CT scans were diagnostic. Surgical removal of the lesion followed by chemotherapy combined with irradiation is the treatment of choice in patients with progressive neurological deterioration in whom chemotherapy alone is ineffective.
Authors:
T Kobayashi; Y Kida; J Yoshida; N Shibuya; N Kageyama
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Surgical neurology     Volume:  17     ISSN:  0090-3019     ISO Abbreviation:  Surg Neurol     Publication Date:  1982 Jun 
Date Detail:
Created Date:  1982-10-12     Completed Date:  1982-10-12     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0367070     Medline TA:  Surg Neurol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  395-403     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Brain Neoplasms / drug therapy,  radiography,  secondary*,  surgery
Choriocarcinoma / drug therapy,  radiography,  secondary*,  surgery
Dactinomycin / therapeutic use
Drug Therapy, Combination
Female
Humans
Methotrexate / therapeutic use
Middle Aged
Pregnancy
Chemical
Reg. No./Substance:
50-76-0/Dactinomycin; 59-05-2/Methotrexate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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