| Brain metastases of non small cell lung cancers: systemic treatments. | |
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MedLine Citation:
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PMID: 23376611 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Chemotherapy, as all systemic treatments, is generally effective in brain metastases because the brain blood barrier (BBB) does not affect treatment's diffusion. Platinum-based chemotherapy provides response rates ranging from 23 to 50% for brain metastases. Anti-EGFR therapies are effective mostly when a somatic EGFR activating mutation is detected, or in selected population (adenocarcinoma, Asian population, never-smokers and women): response rate ranges from 38 to 69.6%. Bevacizumab is now allowed for non-small cell lung cancer (NSCLC) patients with brain metastases and non-squamous histology. The presence of untreated brain metastases may not influence its efficacy combined with paclitaxel-carboplatin. The best sequence for multimodality management of brain metastases has to be established but upfront systemic treatments in patients with asymptomatic brain metastases is a valid option. |
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Authors:
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Marie Chaubet-Houdu; Benjamin Besse |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2013-2-4 |
Journal Detail:
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Title: Bulletin du cancer Volume: - ISSN: 1769-6917 ISO Abbreviation: Bull Cancer Publication Date: 2013 Feb |
Date Detail:
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Created Date: 2013-2-4 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0072416 Medline TA: Bull Cancer Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Institut Gustave-Roussy, Département de Médecine Oncologique, 114, rue Édouard-Vaillant, 94800 Villejuif, France. |
Vernacular Title:
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Métastases cérébrales des cancers bronchiques non à petites cellules : traitement systémique. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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