Document Detail

Brain metastases in Wilms' tumor: case report and literature review.
MedLine Citation:
PMID:  11990704     Owner:  NLM     Status:  MEDLINE    
A 2-year-old girl who had a stage 2, favorable-histology Wilms tumor diagnosed when she was age 10 months presented with multiple brain metastases at second recurrence. She had been treated with combined radiotherapy, surgery, and chemotherapy; at 2 months after treatment, recurrent disease developed in the central nervous system and she died. Brain metastases are rare in the natural history of Wilms tumor. Although it does not appear that cerebral metastases are a barrier to tumor eradication and long-term survival if treated with combined modality therapy, treatment should be individualized.
Rob MacRae; Laval Grimard; Elizabeth Hsu; Elizabeth Nizalik; Jacqueline M Halton
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Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  Journal of pediatric hematology/oncology     Volume:  24     ISSN:  1077-4114     ISO Abbreviation:  J. Pediatr. Hematol. Oncol.     Publication Date:  2002 Feb 
Date Detail:
Created Date:  2002-05-06     Completed Date:  2002-06-04     Revised Date:  2011-10-06    
Medline Journal Info:
Nlm Unique ID:  9505928     Medline TA:  J Pediatr Hematol Oncol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  149-53     Citation Subset:  IM    
Ottawa Regional Cancer Center and the Children's Hospital of Eastern Ontario, Canada.
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MeSH Terms
Antineoplastic Combined Chemotherapy Protocols / therapeutic use
Brain Neoplasms / drug therapy,  radiotherapy,  secondary*,  surgery
Carboplatin / administration & dosage
Combined Modality Therapy
Fatal Outcome
Frontal Lobe*
Ifosfamide / administration & dosage
Kidney Neoplasms* / drug therapy,  surgery
Lung Neoplasms / drug therapy,  radiotherapy,  secondary,  surgery
Mediastinal Neoplasms / drug therapy,  secondary,  surgery
Neoplasm Invasiveness
Neoplasm Recurrence, Local
Occipital Lobe*
Palliative Care
Paresis / etiology
Parietal Lobe*
Wilms Tumor / drug therapy,  radiotherapy,  secondary*,  surgery
Reg. No./Substance:
3778-73-2/Ifosfamide; 41575-94-4/Carboplatin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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