| Brain metabolites B1-corrected proton T1 mapping in the rhesus macaque at 3 T. | |
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MedLine Citation:
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PMID: 20373387 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The accuracy of metabolic quantification in MR spectroscopy is limited by the unknown radiofrequency field and T(1). To address both issues in proton ((1)H) MR spectroscopy, we obtained radiofrequency field-corrected T(1) maps of N-acetylaspartate, choline, and creatine in five healthy rhesus macaques at 3 T. For efficient use of the 4 hour experiment, we used a new three-point protocol that optimizes the precision of T(1) in three-dimensional (1)H-MR spectroscopy localization for extensive, approximately 30%, brain coverage at 0.6 x 0.6 x 0.5 cm(3) = 180-microL spatial resolution. The resulting mean T(1)s in 700 voxels were N-acetylaspartate = 1232 +/- 44, creatine = 1238 +/- 23 and choline = 1107 +/- 56 ms (mean +/- standard error of the mean). Their histograms from all 140 voxels in each animal were similar in position and shape, characterized by standard errors of the mean of the full width at half maximum divided by their means of better than 8%. Regional gray matter N-acetylaspartate, choline, and creatine T(1)s (1333 +/- 43, 1265 +/- 52, and 1131 +/- 28 ms) were 5-10% longer than white matter: 1188 +/- 34, 1201 +/- 24, and 1082 +/- 50 ms (statistically significant for the N-acetylaspartate only), all within 10% of the corresponding published values in the human brain. |
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Authors:
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Songtao Liu; Roman Fleysher; Lazar Fleysher; Chan-Gyu Joo; Eva-Maria Ratai; R Gilberto González; Oded Gonen |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural |
Journal Detail:
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Title: Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine Volume: 63 ISSN: 1522-2594 ISO Abbreviation: Magn Reson Med Publication Date: 2010 Apr |
Date Detail:
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Created Date: 2010-04-07 Completed Date: 2010-07-15 Revised Date: 2011-09-26 |
Medline Journal Info:
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Nlm Unique ID: 8505245 Medline TA: Magn Reson Med Country: United States |
Other Details:
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Languages: eng Pagination: 865-71 Citation Subset: IM |
Affiliation:
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Department of Radiology, New York University School of Medicine, New York, New York, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Analysis of Variance Animals Aspartic Acid / analogs & derivatives, metabolism Brain / metabolism* Brain Mapping Choline / metabolism Creatine / metabolism Image Processing, Computer-Assisted Imaging, Three-Dimensional Macaca mulatta Magnetic Resonance Imaging / methods Magnetic Resonance Spectroscopy / methods* Protons Reproducibility of Results Signal Processing, Computer-Assisted |
| Grant Support | |
ID/Acronym/Agency:
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AI028691/AI/NIAID NIH HHS; EB01015/EB/NIBIB NIH HHS; NS040237/NS/NINDS NIH HHS; NS050041/NS/NINDS NIH HHS; NS050520/NS/NINDS NIH HHS; NS051129/NS/NINDS NIH HHS; NS059331/NS/NINDS NIH HHS; R01 EB001015-15/EB/NIBIB NIH HHS; R01 EB001015-16/EB/NIBIB NIH HHS; R01 NS050520-05/NS/NINDS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Protons; 56-84-8/Aspartic Acid; 57-00-1/Creatine; 62-49-7/Choline; 997-55-7/N-acetylaspartate |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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