Document Detail

Brain metabolic changes associated with predispotion to onset of major depressive disorder and adjustment disorder in cancer patients--a preliminary PET study.
MedLine Citation:
PMID:  16684544     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: To explore neurobiological risk factors for major depressive disorder (MDD) and adjustment disorder in cancer patients by examining regional brain metabolism before psychiatric manifestation using positron emission tomography and by prospectively observing depressive and anxiety symptoms. METHOD: Cancer patients who showed no psychiatric symptoms when they underwent 18F-fluorodeoxyglucose positron emission tomography (18F-FDG PET) were followed up for one year using the Hospital Anxiety and Depression Scale (HADS). Fourteen patients who showed high HADS scores and 14 patients who showed low HADS scores were assessed by a psychiatrist 2 years after the PET scan and grouped into the deterioration group (n=10) and the no-change group (n=9). 18F-FDG PET images were analyzed to examine the difference in local brain glucose metabolism between the two groups. RESULTS: The deterioration group showed a decreased glucose metabolism in the right medial frontal gyrus (BA6) and an increased glucose metabolism in the right posterior cingulate (BA29), right anterior cingulate (BA25), left subcallosal gyrus (BA25), and left caudate compared with the no-change group. CONCLUSION: Cancer patients who later developed MDD or adjustment disorder showed regional brain metabolic changes. These regions may be associated with vulnerability to the onset of MDD or adjustment disorder in cancer patients.
H Kumano; I Ida; A Oshima; K Takahashi; N Yuuki; M Amanuma; N Oriuchi; K Endo; H Matsuda; M Mikuni
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2006-05-08
Journal Detail:
Title:  Journal of psychiatric research     Volume:  41     ISSN:  0022-3956     ISO Abbreviation:  J Psychiatr Res     Publication Date:  2007 Oct 
Date Detail:
Created Date:  2007-03-06     Completed Date:  2007-07-16     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0376331     Medline TA:  J Psychiatr Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  591-9     Citation Subset:  IM    
Department of Psychiatry and Human Behavior, Gunma University Graduate School of Medicine, 3-39-22 Showa-machi, Maebashi, Gunma 371-8511, Japan.
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MeSH Terms
Adjustment Disorders / physiopathology,  radionuclide imaging*
Blood Glucose / metabolism*
Brain / physiopathology,  radionuclide imaging
Cerebral Cortex / physiopathology,  radionuclide imaging
Depressive Disorder, Major / physiopathology,  radionuclide imaging*
Disease Progression
Energy Metabolism / physiology*
Fluorodeoxyglucose F18 / diagnostic use*
Image Processing, Computer-Assisted*
Imaging, Three-Dimensional*
Middle Aged
Neoplasms / psychology*,  radionuclide imaging
Nerve Net / physiopathology,  radionuclide imaging
Personality Inventory
Positron-Emission Tomography*
Sensitivity and Specificity
Reg. No./Substance:
0/Blood Glucose; 63503-12-8/Fluorodeoxyglucose F18

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