Document Detail

Brain mapping with single photon emission CT.
MedLine Citation:
PMID:  9457203     Owner:  NLM     Status:  MEDLINE    
PURPOSE: To investigate the feasibility of performing brain mapping studies by using cortical activation paradigms and single photon emission computed tomography (SPECT) and to evaluate methods of analysis. MATERIALS AND METHODS: Twenty healthy volunteers underwent technetium-99m bicisate SPECT under baseline conditions and during either full-field or right hemifield visual stimulation with a black and white reversing checkerboard pattern. Changes in regional cerebral perfusion were measured by using regions of interest (ROIs) and statistical parametric mapping. RESULTS: ROI analysis identified statistically significant increases in perfusion in the occipital cortex with full-field visual stimulation (mean +/- standard error of the mean percentage change from baseline: left, 8.0 +/- 1.5; right, 6.6 +/- 2.4). With right hemifield visual stimulation, perfusion was significantly increased only in the left occipital cortex (left, 5.2 +/- 1.5; right, -0.2 +/- 1.9). Statistical parametric mapping showed areas of activation (more than 100 voxel clusters showed significant change from baseline at a threshold value of P < or = .005 or z > or = 2.58) in the left primary visual cortex (right hemifield visual stimulation) and in both right and left primary visual areas (full-field visual stimulation). CONCLUSION: Brain mapping studies were preformed with Tc-99m bicisate SPECT, and activation-induced changes were visualized and measured. These methods can be applied to develop improved methods of diagnosis and assessment of treatment outcome in patients with neuropsychiatric disorders.
E Matthew; T C Hill
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Radiology     Volume:  206     ISSN:  0033-8419     ISO Abbreviation:  Radiology     Publication Date:  1998 Feb 
Date Detail:
Created Date:  1998-02-26     Completed Date:  1998-02-26     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0401260     Medline TA:  Radiology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  483-9     Citation Subset:  AIM; IM    
Department of Radiologic Sciences, Beth Israel Deaconess Medical Center-West Campus, Harvard Medical School, Boston, MA 02215, USA.
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MeSH Terms
Brain Mapping / methods*
Cysteine / analogs & derivatives*,  diagnostic use
Evoked Potentials, Visual*
Feasibility Studies
Image Processing, Computer-Assisted / methods
Organotechnetium Compounds / diagnostic use*
Photic Stimulation
Radiopharmaceuticals / diagnostic use*
Tomography, Emission-Computed, Single-Photon* / methods
Visual Cortex / physiology*,  radionuclide imaging
Reg. No./Substance:
0/Organotechnetium Compounds; 0/Radiopharmaceuticals; 0/technetium Tc 99m bicisate; 52-90-4/Cysteine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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