Document Detail


Brain magnetic resonance spectroscopy in obsessive-compulsive disorder: The importance of considering subclinical symptoms of anxiety and depression.
MedLine Citation:
PMID:  21377338     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Brain metabolite concentrations have recently been assessed in different cerebral regions presumably targeted in patients with obsessive-compulsive disorder (OCD) using magnetic resonance spectroscopy (MRS). However, results have been divergent. Possible confounding variables, such as the cerebral localisation of investigated regions and metabolites considered, as well as subclinical symptoms of anxiety and depression, could have affected these MRS profiles. The main goal of this study was to assess MRS metabolite differences between 13 individuals with OCD and 12 matched healthy controls in seven brain regions potentially involved in OCD. The secondary objective was to assess the relationships between levels of anxiety and depression and brain metabolite concentrations. No difference was found for N-acetylaspartate, glutamate-glutamine, myo-inositol (mI) and choline relative to creatine (Cr) concentration in either the left or right orbitofrontal area, left or right median temporal lobe, left or right thalamus or the anterior cingulate cortex. A significant negative correlation between the mI/Cr in the left orbitofrontal area and the severity of OCD symptomatology was observed while subclinical anxiety and depression were closely related to brain metabolite ratios. Thus, these subclinical symptoms, commonly associated with OCD, should be considered in assessing brain metabolite concentrations and may be central to the comprehension of this disorder.
Authors:
Marie-Josée Bédard; Sophie Chantal
Related Documents :
11248608 - Tolterodine once-daily: superior efficacy and tolerability in the treatment of the over...
21395568 - Numinous-like auras and spirituality in persons with partial seizures.
17410558 - Sacral nerve stimulation for neurogenic faecal incontinence.
18067558 - Satisfaction with tolterodine: assessing symptom-specific patient-reported goal achieve...
10480668 - Psychopathology and cognition in schizophrenia spectrum disorders: the role of depressi...
23490008 - Bipolar vs monopolar transurethral resection of the prostate: evaluation of the impact ...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-3-3
Journal Detail:
Title:  Psychiatry research     Volume:  -     ISSN:  0165-1781     ISO Abbreviation:  -     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-3-7     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7911385     Medline TA:  Psychiatry Res     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2010 Elsevier Ireland Ltd. All rights reserved.
Affiliation:
Département de Psychologie, Université du Québec à Trois-Rivières, Trois-Rivieres, Quebec, Canada.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  The loss of asymmetry and reduced interhemispheric connectivity in adolescents with autism: A study ...
Next Document:  In vitro corrosion study of different TiO2 nanotube layers on titanium in solution with serum protei...