Document Detail


Brain magnetic resonance imaging and manganese concentrations in red blood cells of smelting workers: search for biomarkers of manganese exposure.
MedLine Citation:
PMID:  16978697     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The MRI technique has been used in diagnosis of manganism in humans and non-human primates. This cross-sectional study was designed to explore whether the pallidal signal intensity in T1-weighted MRI correlated with Mn levels in the blood compartment among Mn-exposed workers and to understand to what extent the MRI signal could reflect Mn exposure. A group of 18 randomly selected male Mn-exposed workers of which 13 were smelting workers with high exposure (mean of airborne Mn in work place: 1.26 mg/m3; range: 0.31-2.93 mg/m3), and 5 power distribution control workers with low exposure (0.66 mg/m3 and 0.23-0.77 mg/m3) from a ferroalloy factory, and another group of 9 male subjects as controls from a non-smelting factory who were office or cafeteria workers (0.01 mg/m3 and 0-0.03 mg/m3) were recruited for neurological tests, MRI examination, and analysis of Mn in whole blood (MnB), plasma (MnP) or red blood cells (MnRBC). No clinical symptoms and signs of manganism were observed among these workers. MRI data showed average increases of 7.4% (p<0.05) and 16.1% (p<0.01) in pallidal index (PI) among low- and high-exposed workers, respectively, as compared to controls. Fourteen out of 18 Mn-exposed workers (78%) had intensified PI values, while this proportion was even higher (85%) among the high Mn-exposed workers. Among exposed workers, the PI values were significantly associated with MnRBC (r=0.55, p=0.02). Our data suggest that the workers exposed to airborne Mn, but without clinical symptoms, display an exposure-related, intensified MRI signal. The MRI, as well as MnRBC, may be useful in early diagnosis of Mn exposure.
Authors:
Yueming Jiang; Wei Zheng; Liling Long; Weijia Zhao; Xiangrong Li; Xuean Mo; Jipei Lu; Xue Fu; Wenmei Li; Shouting Liu; Quanyong Long; Jinli Huang; Enrico Pira
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2006-08-22
Journal Detail:
Title:  Neurotoxicology     Volume:  28     ISSN:  0161-813X     ISO Abbreviation:  Neurotoxicology     Publication Date:  2007 Jan 
Date Detail:
Created Date:  2007-02-07     Completed Date:  2007-04-09     Revised Date:  2014-06-04    
Medline Journal Info:
Nlm Unique ID:  7905589     Medline TA:  Neurotoxicology     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  126-35     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Air / analysis
Biological Markers
Blood Cell Count
Brain / pathology*
Cross-Sectional Studies
Erythrocytes / chemistry*
Globus Pallidus / drug effects,  metabolism
Humans
Magnetic Resonance Imaging
Male
Manganese / blood*
Metallurgy*
Middle Aged
Occupational Exposure / adverse effects*
Grant Support
ID/Acronym/Agency:
ES-08164/ES/NIEHS NIH HHS; R01 ES008146/ES/NIEHS NIH HHS
Chemical
Reg. No./Substance:
0/Biological Markers; 42Z2K6ZL8P/Manganese
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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