| Brain magnetic resonance imaging in congenital hypothyroid infants at diagnosis. | |
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MedLine Citation:
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PMID: 9349580 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The aim of our study was to investigate the central nervous system (CNS) morphology and myelination with magnetic resonance imaging (MRI) in congenital hypothyroid (CH) infants detected by neonatal screening before replacement therapy. We studied 11 CH infants, 9 girls and 2 boys, mean age 22 days, 3 with aplasia, 5 with ectopia, 2 with hypoplasia of the thyroid gland, 1 with unknown diagnosis. As normal controls 22 term newborns (38 to 41 weeks of gestational age) were studied. MRI studies were performed with a 1.5-T magnet, extremity coil, T1-weighted and heavily T2-sequences axial sections were obtained. No sedation was needed for the MRI studies. MRI brain examination was normal in all patients compared with controls. In particular, no differences in the myelination patterns of the brain were observed between normal subjects and patients with hypothyroidism. Our study shows no morphological brain abnormalities in CH infants detected by neonatal screening before replacement therapy. Perinatal hypothyroidism seems to have no effect on CNS structures. |
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Authors:
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V Siragusa; S Boffelli; G Weber; F Triulzi; S Orezzi; G Scotti; G Chiumello |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Thyroid : official journal of the American Thyroid Association Volume: 7 ISSN: 1050-7256 ISO Abbreviation: Thyroid Publication Date: 1997 Oct |
Date Detail:
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Created Date: 1997-11-13 Completed Date: 1997-11-13 Revised Date: 2005-11-17 |
Medline Journal Info:
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Nlm Unique ID: 9104317 Medline TA: Thyroid Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 761-4 Citation Subset: IM |
Affiliation:
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Department of Pediatrics, Scientific Institute H San Raffaele, University of Milan, Italy. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Brain
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pathology* Congenital Hypothyroidism Female Humans Hypothyroidism / diagnosis* Infant Infant, Newborn Magnetic Resonance Imaging Male Myelin Sheath / pathology |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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