Document Detail

Brain magnetic resonance imaging in congenital hypothyroid infants at diagnosis.
MedLine Citation:
PMID:  9349580     Owner:  NLM     Status:  MEDLINE    
The aim of our study was to investigate the central nervous system (CNS) morphology and myelination with magnetic resonance imaging (MRI) in congenital hypothyroid (CH) infants detected by neonatal screening before replacement therapy. We studied 11 CH infants, 9 girls and 2 boys, mean age 22 days, 3 with aplasia, 5 with ectopia, 2 with hypoplasia of the thyroid gland, 1 with unknown diagnosis. As normal controls 22 term newborns (38 to 41 weeks of gestational age) were studied. MRI studies were performed with a 1.5-T magnet, extremity coil, T1-weighted and heavily T2-sequences axial sections were obtained. No sedation was needed for the MRI studies. MRI brain examination was normal in all patients compared with controls. In particular, no differences in the myelination patterns of the brain were observed between normal subjects and patients with hypothyroidism. Our study shows no morphological brain abnormalities in CH infants detected by neonatal screening before replacement therapy. Perinatal hypothyroidism seems to have no effect on CNS structures.
V Siragusa; S Boffelli; G Weber; F Triulzi; S Orezzi; G Scotti; G Chiumello
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Thyroid : official journal of the American Thyroid Association     Volume:  7     ISSN:  1050-7256     ISO Abbreviation:  Thyroid     Publication Date:  1997 Oct 
Date Detail:
Created Date:  1997-11-13     Completed Date:  1997-11-13     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  9104317     Medline TA:  Thyroid     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  761-4     Citation Subset:  IM    
Department of Pediatrics, Scientific Institute H San Raffaele, University of Milan, Italy.
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MeSH Terms
Brain / pathology*
Congenital Hypothyroidism
Hypothyroidism / diagnosis*
Infant, Newborn
Magnetic Resonance Imaging
Myelin Sheath / pathology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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