Document Detail


Brain magnetic resonance imaging in suspected extrapyramidal cerebral palsy: observations in distinguishing genetic-metabolic from acquired causes.
MedLine Citation:
PMID:  9290610     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Experienced clinicians recognize that some children who appear to have static cerebral palsy (CP) actually have underlying genetic-metabolic disorders. We report a series of patients with motor disorders seen in children with extrapyramidal CP in whom brain magnetic resonance imaging abnormalities provided important diagnostic clues in distinguishing genetic-metabolic disorders from other causes. One cause of static extrapyramidal CP, hypoxic-ischemic encephalopathy at the end of a term gestation, produces a characteristic pattern of hyperintense signal and atrophy in the putamen and thalamus. Other signal abnormalities and atrophy in the putamen, globus pallidus, or caudate can point to genetic-metabolic diseases, including disorders of mitochondrial and organic acid metabolism. Progress in understanding and treating genetic diseases of the developing brain makes it essential to diagnose disorders that masquerade as static CP. Brain magnetic resonance imaging is a useful diagnostic tool in the initial evaluation of children who appear to have CP.
Authors:
A H Hoon; E M Reinhardt; R I Kelley; S N Breiter; D H Morton; S B Naidu; M V Johnston
Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of pediatrics     Volume:  131     ISSN:  0022-3476     ISO Abbreviation:  J. Pediatr.     Publication Date:  1997 Aug 
Date Detail:
Created Date:  1997-10-02     Completed Date:  1997-10-02     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0375410     Medline TA:  J Pediatr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  240-5     Citation Subset:  AIM; IM    
Affiliation:
Department of Developmental Pediatrics, Kennedy Krieger Institute, Baltimore, MD 21205, USA.
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MeSH Terms
Descriptor/Qualifier:
Acidosis, Lactic / diagnosis
Atrophy
Basal Ganglia Diseases / diagnosis*
Brain / pathology*
Brain Diseases / diagnosis*,  genetics,  metabolism
Brain Ischemia / diagnosis
Caudate Nucleus / pathology
Cerebellum / pathology
Cerebral Palsy / diagnosis*
Child, Preschool
Diagnosis, Differential
Female
Globus Pallidus / pathology
Humans
Huntington Disease / diagnosis
Hypoxia, Brain / diagnosis
Infant
Magnetic Resonance Imaging*
Male
Metabolism, Inborn Errors / diagnosis
Mitochondrial Encephalomyopathies / diagnosis
Movement Disorders / diagnosis
Pantothenate Kinase-Associated Neurodegeneration / diagnosis
Putamen / pathology
Pyruvate Dehydrogenase Complex Deficiency Disease / diagnosis
Thalamus / pathology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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