Document Detail


Brain magnetic resonance elastography on healthy volunteers: a safety study.
MedLine Citation:
PMID:  19241188     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Magnetic resonance elastography (MRE) is a recently developed imaging technique that can directly visualize and quantitatively measure tissue elasticity. PURPOSE: To evaluate the safety of brain MRE on human subjects. MATERIAL AND METHODS: The study included 20 healthy volunteers. MRE sequence scan (drive signal not applied to external force actuator) and MRE study were separately performed on each volunteer at an interval of more than 24 hours. The heart rate and blood pressure of each volunteer were measured immediately before and after MRE sequence scan and MRE study. Electroencephalography (EEG) was also performed within 2 hours after each scan. The volunteers were asked about their experience of the two scans. Randomized-block analysis of variance (ANOVA) was used to analyze the data of blood pressure and heart rate. Paired t test was used to analyze the data of the two EEG examinations. The volunteers were followed up 1 week after the examination. RESULTS: All procedures were performed on each volunteer, and no one complained of obvious discomfort. No related adverse events were reported during follow-up. There was no statistically significant difference in heart rate or blood pressure. There was a statistically significant difference (P<0.05) in EEG results in the right temporoparietal region. Increased power was found in the theta, delta, alpha, and beta2 bands. No brain injury was detected by the EEG examinations. CONCLUSION: Based on the study results, brain MRE examinations are safe to perform on human subjects.
Authors:
Guang-Rui Liu; Pei-Yi Gao; Yan Lin; Jing Xue; Xiao-Chun Wang; Bin-Bin Sui; Li Ma; Zhi-Nong Xi; Qin Bai; Hao Shen
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Acta radiologica (Stockholm, Sweden : 1987)     Volume:  50     ISSN:  1600-0455     ISO Abbreviation:  Acta Radiol     Publication Date:  2009 May 
Date Detail:
Created Date:  2009-04-17     Completed Date:  2009-05-05     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8706123     Medline TA:  Acta Radiol     Country:  Sweden    
Other Details:
Languages:  eng     Pagination:  423-9     Citation Subset:  IM    
Affiliation:
Imaging Center of Neuroradiology, Beijing Neurosurgical Institute, Affiliated Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
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MeSH Terms
Descriptor/Qualifier:
Adult
Blood Pressure
Brain / physiology*
Elasticity Imaging Techniques* / adverse effects
Electroencephalography
Female
Heart Rate
Humans
Male
Middle Aged
Reference Values

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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