Document Detail

Brain, liver and plasma unsaturated aldehydes in nutritional encephalomalacia of chicks.
MedLine Citation:
PMID:  10842464     Owner:  NLM     Status:  MEDLINE    
Vitamin E deficiency and linoleic acid-feeding lead to nutritional encephalomalacia (NE) in chicks, affecting the cerebellum exclusively. The relevance of lipid peroxidation (LPO) products to the pathogenesis of the disease was studied. Laying hens received a diet low in vitamin E. Resulting chicks were assigned to four groups fed either with linoleic (C18: 2n-6) or linolenic (C18: 3n-3) acid together with 1 or 50 p.p.m. vitamin E. Nine days post-hatching NE occurred in the vitamin E-deficient group fed linoleic acid. With each chick showing NE, a healthy one from all four groups was killed. Unsaturated aldehydes were determined in plasma, liver, cerebrum and cerebellum. Results underlined that the type of dietary fat is decisive for the aldehyde pattern. In the liver of linoleic acid-fed animals total aldehydes were increased. Diseased animals had increased aldehydes stemming from n-3 fatty acids. In plasma, vitamin E deficiency led to higher malondialdehyde and OH-nonenal concentrations. In brain, neither vitamin E deficiency nor NE were accompanied by increased aldehyde concentrations. In consequence a direct role of unsaturated aldehydes for the development of NE in the cerebellum is not probable.
H Fuhrmann; H P Sallmann
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of veterinary medicine. A, Physiology, pathology, clinical medicine     Volume:  47     ISSN:  0931-184X     ISO Abbreviation:  J Vet Med A Physiol Pathol Clin Med     Publication Date:  2000 Apr 
Date Detail:
Created Date:  2000-07-06     Completed Date:  2000-07-06     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  100955112     Medline TA:  J Vet Med A Physiol Pathol Clin Med     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  149-55     Citation Subset:  IM    
Institute of Physiological Chemistry, School of Veterinary Medicine Hannover, Germany.
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MeSH Terms
Aldehydes / analysis*
Animal Feed
Brain Chemistry*
Dietary Fats / administration & dosage
Encephalomalacia / etiology,  metabolism,  veterinary*
Fatty Acids / administration & dosage
Lipid Peroxidation
Liver / chemistry*
Poultry Diseases / etiology,  metabolism*
Random Allocation
Vitamin E Deficiency / complications,  veterinary*
Reg. No./Substance:
0/Aldehydes; 0/Dietary Fats; 0/Fatty Acids

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