Document Detail

Brain lesions in an infant rhesus monkey treated with monsodium glutamate.
MedLine Citation:
PMID:  5812037     Owner:  NLM     Status:  MEDLINE    
In an infant rhesus monkey brain damage resulted from subcutaneously administered monosodium glutamate. Although a relatively high dose of monosodium glutamate was used, the infant was asymptomatic for a 3-hour observation period during which time hypothalamic neurons were undergoing a process of acute cell death. With the electron microscope it was observed that dendrites and cell bodies of neurons are the tissue components primarily affected in brain damage induced by monosodium glutamate.
J W Olney; L G Sharpe
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Science (New York, N.Y.)     Volume:  166     ISSN:  0036-8075     ISO Abbreviation:  Science     Publication Date:  1969 Oct 
Date Detail:
Created Date:  1969-10-31     Completed Date:  1969-10-31     Revised Date:  2011-12-07    
Medline Journal Info:
Nlm Unique ID:  0404511     Medline TA:  Science     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  386-8     Citation Subset:  IM    
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MeSH Terms
Animals, Newborn*
Brain Diseases / chemically induced*,  pathology
Dendrites / drug effects
Food Additives
Glutamates* / blood
Hypothalamus / drug effects
Injections, Subcutaneous
Microscopy, Electron
Reg. No./Substance:
0/Food Additives; 0/Glutamates; 7440-23-5/Sodium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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