Document Detail

Brain lactate in preterm and growth-retarded neonates.
MedLine Citation:
PMID:  7633142     Owner:  NLM     Status:  MEDLINE    
Glucose is the predominant cerebral energy source under physiological conditions, although other substrates may support cerebral metabolism. The present study was undertaken to determine if lactate is present in the immature human brain, and if so, whether or not concentrations of lactate differ between small-for-gestational-age and appropriate-for-gestational-age infants. Thirty stable, healthy infants with normal brains were investigated. As the only nutrient, all received milk enterally prior to the investigation, which was carried out without sedation. Mean gestational age was 35 completed weeks (range 28-41 weeks) and mean birth weight was 2170 g (range 855-4100 g). Proton nuclear magnetic resonance spectra from the striatal region were obtained while the infants were sleeping quietly. Lactate was present in all 10 preterm small-for-gestational-age and 10 of 13 preterm appropriate-for-gestational-age infants, and the concentration was inversely related to postmenstrual age (p < 0.002). In addition, lactate increased with the degree of growth retardation (p < 0.01). At present the significance of lactate is unclear. Lactate may be produced locally or in peripheral tissues, and may support brain metabolism.
H Leth; P B Toft; O Pryds; B Peitersen; H C Lou; O Henriksen
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Acta paediatrica (Oslo, Norway : 1992)     Volume:  84     ISSN:  0803-5253     ISO Abbreviation:  Acta Paediatr.     Publication Date:  1995 May 
Date Detail:
Created Date:  1995-09-11     Completed Date:  1995-09-11     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9205968     Medline TA:  Acta Paediatr     Country:  NORWAY    
Other Details:
Languages:  eng     Pagination:  495-9     Citation Subset:  IM    
Department of Pediatrics, University Hospital, Hvidovre, Denmark.
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MeSH Terms
Brain / metabolism*
Corpus Striatum / metabolism
Fetal Growth Retardation / metabolism*
Infant, Newborn
Infant, Premature / metabolism*
Lactates / metabolism*
Lactic Acid
Magnetic Resonance Spectroscopy / diagnostic use
Reg. No./Substance:
0/Lactates; 50-21-5/Lactic Acid

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