| Brain lactate by magnetic resonance spectroscopy during fulminant hepatic failure in the dog. | |
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MedLine Citation:
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PMID: 9516569 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A noninvasive test is needed to assess the severity of encephalopathy during fulminant hepatic failure. This feasibility study was designed to compare a noninvasive test, brain lactate measurement by magnetic resonance spectroscopy, with intracranial pressure monitoring in a large animal model of fulminant hepatic failure. Five dogs received an intraventricular catheter for intracranial pressure measurement. Liver injury was induced by intravenous bolus of D-galactosamine. Brain lactate concentrations were determined by magnetic resonance spectroscopy for up to 48 hours after D-galactosamine administration (t = 0 hour). A dose of D-galactosamine exceeding 1.5 g/kg resulted in fulminant hepatic failure. Brain lactate levels increased to > 10 mmol/L in the two dogs that developed severe intracranial hypertension of > 50 mm Hg and sustained cerebral perfusion pressures of < 40 mm Hg. Both dogs experienced brain death, 42 and 48 hours after the administration of D-galactosamine. Brain lactate concentrations determined by magnetic resonance spectroscopy were in agreement with brain tissue concentrations of lactate determined by high-performance liquid chromatography at necropsy. Plasma lactate concentrations were only mildly elevated (3.2 and 4.2 mmol/L) at the time of brain death. Elevated levels of brain lactate are associated with intracranial hypertension and poor neurological outcome during fulminant hepatic failure. |
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Authors:
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S L Nyberg; F B Cerra; R Gruetter |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Liver transplantation and surgery : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society Volume: 4 ISSN: 1074-3022 ISO Abbreviation: Liver Transpl Surg Publication Date: 1998 Mar |
Date Detail:
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Created Date: 1998-05-28 Completed Date: 1998-05-28 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 9502504 Medline TA: Liver Transpl Surg Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 158-65 Citation Subset: IM |
Affiliation:
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Department of Surgery, Mayo Medical Center, Rochester, MN 55905, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Biological Markers / analysis Brain / metabolism* Dogs Dose-Response Relationship, Drug Feasibility Studies Galactosamine / pharmacology Glutamic Acid / metabolism Glutamine / metabolism Hepatic Encephalopathy / chemically induced, metabolism*, pathology, physiopathology Intracranial Hypertension / physiopathology* Lactic Acid / blood, metabolism* Magnetic Resonance Spectroscopy Male Time Factors |
| Grant Support | |
ID/Acronym/Agency:
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RR08079/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 50-21-5/Lactic Acid; 56-85-9/Glutamine; 56-86-0/Glutamic Acid; 7535-00-4/Galactosamine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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