Document Detail

Brain involvement in generalized argyria.
MedLine Citation:
PMID:  6705320     Owner:  NLM     Status:  MEDLINE    
Cutaneous argyria was diagnosed in a 59-year-old woman. Manic depressive psychosis developed at about the same or a short time thereafter. The patient died 6 years later from a ruptured aortic aneurysm. At autopsy silver deposits were seen in skin, mucous membranes, heart, kidney, and liver. In the central nervous system the leptomeninges and choroid plexuses contained silver granules. In addition, silver granules were visualized in the walls of many intraparenchymal vessels, particularly of the basal ganglia, hypothalamus, substantia nigra, and cerebellum. Progressive glial changes and cellular gliosis were evident in many areas of the brain. With the electron microscope the deposition of silver granules in basal membrane structures of the choroid plexus and intracerebral vasculature was amply confirmed. Furthermore, silver deposition was seen in brain parenchymal cells inside bodies of apparently lysosomal nature. The silver content of various brain regions was determined by absorption spectrophotometry.
H W Dietl; A P Anzil; P Mehraein
Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Clinical neuropathology     Volume:  3     ISSN:  0722-5091     ISO Abbreviation:  Clin. Neuropathol.     Publication Date:    1984 Jan-Feb
Date Detail:
Created Date:  1984-05-11     Completed Date:  1984-05-11     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8214420     Medline TA:  Clin Neuropathol     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  32-6     Citation Subset:  IM    
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MeSH Terms
Argyria / complications,  etiology,  pathology*
Basement Membrane / analysis
Bipolar Disorder / complications
Blood-Brain Barrier
Brain / pathology*
Choroid Plexus / pathology
Meninges / pathology
Microscopy, Electron
Middle Aged
Self Medication
Silver Nitrate / administration & dosage,  analysis
Skin Diseases / complications
Reg. No./Substance:
7761-88-8/Silver Nitrate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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