| Brain injury in chronically ventilated preterm neonates: collateral damage related to ventilation strategy. | |
| | |
MedLine Citation:
|
PMID: 22954278 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Brain injury is a frequent comorbidity in chronically ventilated preterm infants. However, the molecular basis of the brain injury remains incompletely understood. This article discusses the subtle (diffuse) form of brain injury that has white matter and gray matter lesions without germinal matrix hemorrhage-intraventricular hemorrhage, posthemorrhagic hydrocephalus, or cystic periventricular leukomalacia. This article synthesizes data that suggest that diffuse lesions to white matter and gray matter are collateral damage related to ventilator strategy. Evidence is introduced from the 2 large-animal, physiologic models of evolving neonatal chronic lung disease that suggest that an epigenetic mechanism may underlie the collateral damage. |
| | |
Authors:
|
Kurt H Albertine |
Related Documents
:
|
512558 - A preliminary report of mortality patterns among foundry workers. 20669598 - Current trends in irish perinatal mortality. 16553938 - Analysis of deaths with an unknown cause in epidemiologic analyses of mortality burden. 7287288 - Seasonality of deaths in matlab, bangladesh. 7188718 - Congenital torulopsis glabrata infection in man. 11300638 - The association of unilateral congenital glaucoma and congenital lower lid entropion: c... |
Publication Detail:
|
Type: Journal Article; Research Support, N.I.H., Extramural; Review |
Journal Detail:
|
Title: Clinics in perinatology Volume: 39 ISSN: 1557-9840 ISO Abbreviation: Clin Perinatol Publication Date: 2012 Sep |
Date Detail:
|
Created Date: 2012-09-07 Completed Date: 2013-02-11 Revised Date: 2013-04-16 |
Medline Journal Info:
|
Nlm Unique ID: 7501306 Medline TA: Clin Perinatol Country: United States |
Other Details:
|
Languages: eng Pagination: 727-40 Citation Subset: IM |
Copyright Information:
|
Copyright © 2012 Elsevier Inc. All rights reserved. |
Affiliation:
|
Department of Pediatrics, University of Utah School of Medicine, Salt Lake City, UT 84158, USA. kurt.albertine@hsc.utah.edu |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Brain / embryology Brain Injuries / etiology* Humans Infant, Newborn Infant, Premature* Lung Diseases / complications*, therapy* Respiration, Artificial / adverse effects* |
| Grant Support | |
ID/Acronym/Agency:
|
HL062875/HL/NHLBI NIH HHS; HL110002/HL/NHLBI NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Cell-based strategies to reconstitute lung function in infants with severe bronchopulmonary dysplasi...
Next Document: A new duplication in the mitochondrially encoded tRNA proline gene in a patient with dilated cardiom...