Document Detail


Brain injury in chronically ventilated preterm neonates: collateral damage related to ventilation strategy.
MedLine Citation:
PMID:  22954278     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Brain injury is a frequent comorbidity in chronically ventilated preterm infants. However, the molecular basis of the brain injury remains incompletely understood. This article discusses the subtle (diffuse) form of brain injury that has white matter and gray matter lesions without germinal matrix hemorrhage-intraventricular hemorrhage, posthemorrhagic hydrocephalus, or cystic periventricular leukomalacia. This article synthesizes data that suggest that diffuse lesions to white matter and gray matter are collateral damage related to ventilator strategy. Evidence is introduced from the 2 large-animal, physiologic models of evolving neonatal chronic lung disease that suggest that an epigenetic mechanism may underlie the collateral damage.
Authors:
Kurt H Albertine
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review    
Journal Detail:
Title:  Clinics in perinatology     Volume:  39     ISSN:  1557-9840     ISO Abbreviation:  Clin Perinatol     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-09-07     Completed Date:  2013-02-11     Revised Date:  2014-04-07    
Medline Journal Info:
Nlm Unique ID:  7501306     Medline TA:  Clin Perinatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  727-40     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier Inc. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Animals
Brain / embryology
Brain Injuries / etiology*
Humans
Infant, Newborn
Infant, Premature*
Lung Diseases / complications*,  therapy*
Respiration, Artificial / adverse effects*
Grant Support
ID/Acronym/Agency:
HL062875/HL/NHLBI NIH HHS; HL110002/HL/NHLBI NIH HHS; R01 HL062875/HL/NHLBI NIH HHS; R01 HL110002/HL/NHLBI NIH HHS
Comments/Corrections

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