Document Detail


Brain injury following trial of hypothermia for neonatal hypoxic-ischaemic encephalopathy.
MedLine Citation:
PMID:  23080477     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: The objective of our study was to examine the relationship between brain injury and outcome following neonatal hypoxic-ischaemic encephalopathy treated with hypothermia.
DESIGN AND PATIENTS: Neonatal MRI scans were evaluated in the National Institute of Child Health and Human Development (NICHD) randomised controlled trial of whole-body hypothermia and each infant was categorised based upon the pattern of brain injury on the MRI findings. Brain injury patterns were assessed as a marker of death or disability at 18-22 months of age.
RESULTS: Scans were obtained on 136 of 208 trial participants (65%); 73 in the hypothermia and 63 in the control group. Normal scans were noted in 38 of 73 infants (52%) in the hypothermia group and 22 of 63 infants (35%) in the control group. Infants in the hypothermia group had fewer areas of infarction (12%) compared to infants in the control group (22%). Fifty-one of the 136 infants died or had moderate or severe disability at 18 months. The brain injury pattern correlated with outcome of death or disability and with disability among survivors. Each point increase in the severity of the pattern of brain injury was independently associated with a twofold increase in the odds of death or disability.
CONCLUSIONS: Fewer areas of infarction and a trend towards more normal scans were noted in brain MRI following whole-body hypothermia. Presence of the NICHD pattern of brain injury is a marker of death or moderate or severe disability at 18-22 months following hypothermia for neonatal encephalopathy.
Authors:
Seetha Shankaran; Patrick D Barnes; Susan R Hintz; Abbott R Laptook; Kristin M Zaterka-Baxter; Scott A McDonald; Richard A Ehrenkranz; Michele C Walsh; Jon E Tyson; Edward F Donovan; Ronald N Goldberg; Rebecca Bara; Abhik Das; Neil N Finer; Pablo J Sanchez; Brenda B Poindexter; Krisa P Van Meurs; Waldemar A Carlo; Barbara J Stoll; Shahnaz Duara; Ronnie Guillet; Rosemary D Higgins;
Related Documents :
17587927 - Cause-specific infant mortality rate in qatif area, eastern province, saudi arabia.
20634347 - Time of birth and risk of neonatal death at term: retrospective cohort study.
19116907 - Association of the traf1/c5 locus with increased mortality, particularly from malignanc...
2592177 - Sudden death in young israeli soldiers. analysis of 83 cases.
12067087 - The radioprotective effects of bu-zhong-yi-qi-tang: a prescription of traditional chine...
22664097 - Information on infantile colic on the world wide web.
Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Archives of disease in childhood. Fetal and neonatal edition     Volume:  97     ISSN:  1468-2052     ISO Abbreviation:  Arch. Dis. Child. Fetal Neonatal Ed.     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-10-19     Completed Date:  2013-02-05     Revised Date:  2014-04-01    
Medline Journal Info:
Nlm Unique ID:  9501297     Medline TA:  Arch Dis Child Fetal Neonatal Ed     Country:  England    
Other Details:
Languages:  eng     Pagination:  F398-404     Citation Subset:  AIM; IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Brain Injuries / etiology*,  pathology
Female
Humans
Hypothermia, Induced*
Hypoxia-Ischemia, Brain / complications,  mortality,  therapy*
Infant
Infant, Newborn
Magnetic Resonance Imaging
Male
Severity of Illness Index
Treatment Outcome
Grant Support
ID/Acronym/Agency:
U10 HD021364/HD/NICHD NIH HHS; U10 HD021385/HD/NICHD NIH HHS
Investigator
Investigator/Affiliation:
Seetha Shankaran / ; Patrick D Barnes / ; Susan R Hintz / ; Abbott R Laptook / ; Kristin M Zaterka-Baxter / ; Scott A McDonald / ; Richard A Ehrenkranz / ; Michele C Walsh / ; Jon E Tyson / ; Edward F Donovan / ; Ronald N Goldberg / ; Rebecca Bara / ; Abhik Das / ; Neil N Finer / ; Pablo J Sanchez / ; Brenda B Poindexter / ; Krisa P Van Meurs / ; Waldemar A Carlo / ; Barbara J Stoll / ; Shahnaz Duara / ; Ronnie Guillet / ; Rosemary D Higgins / ; Alan H Jobe / ; Michael S Caplan / ; William Oh / ; Betty R Vohr / ; Bonnie E Stephens / ; Theresa M Leach / ; Angelita M Hensman / ; Lucy Noel / ; Victoria E Watson / ; Avory A Fanaroff / ; Deanne E Wilson-Costello / ; Nancy Bass / ; Harriet G Friedman / ; Nancy S Newman / ; Bonnie S Siner / ; Kurt Schibler / ; Kate Bridges / ; Jean J Steichen / ; Kimberly Yolton / ; Barbara Alexander / ; Cathy Grisby / ; Holly L Mincey / ; Jody Hessling / ; Teresa L Gratton / ; C Michael Cotten / ; Kathryn E Gustafson / ; Ricki F Goldstein / ; Kathy J Auten / ; Kimberley A Fisher / ; Sandy Grimes / ; Melody B Lohmeyer / ; Ira Adams-Chapman / ; Lucky Jain / ; Ann M Blackwelder / ; Ellen C Hale / ; Sobha Fritz / ; Sheena Carter / ; Maureen Mulligan LaRossa / ; Linda L Wright / ; Elizabeth M McClure / ; James A Lemons / ; Anna M Dusick / ; Lucy C Miller / ; Leslie Richard / ; Leslie Dawn Wilson / ; W Kenneth Poole / ; Jeanette O'Donnell Auman / ; Margaret Cunningham / ; Betty K Hastings / ; Jamie E Newman / ; Carolyn M Petrie Huitema / ; Scott E Schaefer / ; David K Stevenson / ; Susan R Hintz / ; M Bethany Ball / ; Barry E Fleisher / ; Anne M DeBattista / ; Joan M Baran / ; Julie C Lee-Ancajas / ; Namasivayam Ambalavanan / ; Myriam Peralta-Carcelen / ; Kathleen G Nelson / ; Monica V Collins / ; Shirley S Cosby / ; Vivien A Phillips / ; Fred J Biasini / ; Kirstin J Bailey / ; Martha G Fuller / ; Radmila West / ; David Kaegi / ; Maynard R Rasmussen / ; Yvonne E Vaucher / ; Kathy Arnell / ; Chris Henderson / ; Wade Rich / ; Charles R Bauer / ; Sylvia Hiriart-Fajardo / ; Mary Allison / ; Maria Calejo / ; Ruth Everett-Thomas / ; Silvia M Frade Eguaras / ; Susan Gauthier / ; Dale L Phelps / ; Rosemary Jensen / ; Linda J Reubens / ; Pablo J Sánchez / ; R Sue Broyles / ; Charles R Rosenfeld / ; Walid A Salhab / ; Roy J Heyne / ; Cathy Boatman / ; Cristin Dooley / ; Gaynelle Hensley / ; Jackie F Hickman / ; Susie Madison / ; Nancy A Miller / ; Janet S Morgan / ; Alicia Guzman / ; Elizabeth Heyne / ; Linda A Madden / ; Sally Adams / ; Kathleen A Kennedy / ; Esther G Akpa / ; Patty A Cluff / ; Claudia Y Franco / ; Anna E Lis / ; Georgia E McDavid / ; Patti L Tate / ; Nora I Alaniz / ; Pamela J Bradt / ; Magda Cedillo / ; Susan Dieterich / ; Terri Major-Kincade / ; Brenda H Morris / ; Maegan C Simmons / ; Laura L Whitely / ; Geraldine Muran / ; Yvette R Johnson / ; Deborah Kennedy / ; Laura A Goldston / ; Patricia Gettner / ; Monica Konstantino / ; JoAnn Poulsen / ; Elaine Romano / ; Joanne Williams / ; Mary E D'Alton / ; J C Fletcher / ; Christine A Gleason / ; Carol K Redmond / ; Marian Willinger /
Comments/Corrections
Erratum In:
Arch Dis Child Fetal Neonatal Ed. 2014 Mar;99(3):301

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  The use of customized TKA implants for increased efficiency in the OR.
Next Document:  Maternal use of SSRIs, SNRIs and NaSSAs: practical recommendations during pregnancy and lactation.