| Brain inflammation induced by severe asphyxia in newborn pigs and the impact of alternative resuscitation strategies on the newborn central nervous system. | |
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MedLine Citation:
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PMID: 23168577 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Background:We compared current guidelines for neonatal resuscitation to alternative measures and aimed to find if this modulated brain inflammation.Methods:Progressive asphyxia was induced in 94 newborn pigs until asystole. With the reference being resuscitation guidelines, 30s of initial positive pressure ventilation before compressions and ventilations (C:V) 3:1 in 21% oxygen, pigs were randomized to 1) ventilation for 30s, 60s or 90s before chest compressions or 2) C:V ratios 3:1, 9:3 or 15:2 or 3) 21% or 100% oxygen. Concentrations in cerebrospinal fluid (CSF) and gene expression in hippocampus and frontal cortex of inflammatory markers were measured for the different interventions.Results:In CSF, S100 was higher with 90s than 30s and 60s of initial positive pressure ventilation, whereas concentrations of IL6 and TNFα were higher with 30s than 60s. Matrix metalloproteinase 2 (MMP2) and intracellular adhesion molecule 1 (ICAM-1) were higher with 30s than 60s. All other comparisons between ratios and oxygen concentrations used were similar.Conclusion:With respect to signs of brain inflammation newly born pigs at asystole should be ventilated longer than 30s before chest compressions start. Ratios 9:3 and 15:2 compared to 3:1, or air instead of pure oxygen, did not modulate inflammatory markers.Pediatric Research (2012); doi:10.1038/pr.2012.167. |
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Authors:
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Ingrid Dannevig; Anne Lee Solevåg; Tonje Sonerud; Ola Didrik Saugstad; Britt Nakstad |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-11-20 |
Journal Detail:
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Title: Pediatric research Volume: - ISSN: 1530-0447 ISO Abbreviation: Pediatr. Res. Publication Date: 2012 Nov |
Date Detail:
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Created Date: 2012-11-21 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0100714 Medline TA: Pediatr Res Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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1] Department of Paediatrics, Akershus University Hospital, N-1478 Lørenskog, Norway [2] Institute of Clinical Medicine, University of Oslo, N-1474 Lørenskog, Norway [3] Department of Paediatric Research, Oslo University Hospital, Rikshospitalet, P.O. Box 4950 Nydalen, N-0424 Oslo, Norway [4] Institute for Surgical Research, Oslo University Hospital, Rikshospitalet, P.O. Box 4950 Nydalen, N-0424 Oslo, Norway. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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