Document Detail


Brain imaging in transient ischemic attack--redefining TIA.
MedLine Citation:
PMID:  20605469     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Transient ischemic attack (TIA) has recently been redefined to incorporate the latest clinical and neuroimaging information that has shed new light on TIA pathophysiology. Patients suffering from TIA are at a substantial risk of subsequent stroke, but quantifying this risk is difficult as TIA patients are a heterogeneous population and there are multiple TIA mimics. Clinical scores for prediction of stroke risk are principally based on patient history and potentially understate actual risk. Magnetic resonance imaging (MRI), in particular diffusion-weighted imaging (DWI) performed in the first days following TIA, reveals relevant focal ischemic abnormalities in 21-68% of patients. These lesions predict stroke recurrence, functional dependence and subsequent vascular events. Adding imaging information to clinical scores improves prediction of stroke risk following TIA. Alongside clinical judgement, use of MRI has the potential to change the management of TIA patients and is the imaging modality of choice for this condition.
Authors:
Aleksandra M Pavlovic; Christen D Barras; Peter J Hand; Brian M Tress; Patricia M Desmond; Stephen M Davis
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2010-06-03
Journal Detail:
Title:  Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia     Volume:  17     ISSN:  1532-2653     ISO Abbreviation:  J Clin Neurosci     Publication Date:  2010 Sep 
Date Detail:
Created Date:  2010-07-30     Completed Date:  2011-01-28     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9433352     Medline TA:  J Clin Neurosci     Country:  Scotland    
Other Details:
Languages:  eng     Pagination:  1105-10     Citation Subset:  IM    
Copyright Information:
Copyright 2010 Elsevier Ltd. All rights reserved.
Affiliation:
Department of Neurology, Royal Melbourne Hospital, Grattan Street, Parkville, Melbourne, Victoria 3050, Australia.
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MeSH Terms
Descriptor/Qualifier:
Brain / pathology*
Humans
Ischemic Attack, Transient / complications*,  diagnosis*
Magnetic Resonance Imaging* / methods
Risk Factors
Stroke / diagnosis,  etiology,  prevention & control

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