| Brain imaging findings predict blood pressure response to pharmacological treatment. | |
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MedLine Citation:
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PMID: 18981325 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Hypertension appears to alter brain morphology, as well as the cerebrovascular support for information processing. Because these effects might reflect progressive effects of essential hypertension on the brain, we asked whether structural and functional brain indices would predict the success of pharmacological treatment of hypertension among 45 previously unmedicated individuals. After initial structural MRI and functional positron emission tomography imaging, subjects were randomly assigned in a double-blind fashion for treatment for 1 year with either lisinopril or atenolol. Systolic and diastolic blood pressure decreases after treatment stabilization were correlated to a pretreatment index of brain aging (combined ratings of ventricle and sulcal size and white matter hyperintensities) and the pretreatment change in regional cerebral blood flow during working memory in the thalamus and posterior parietal regions of interest. In multiple regression analyses, the structural brain index and the blood flow response in the thalamus predicted 20% of the variance in the systolic blood pressure response to treatment controlling for pretreatment blood pressure, age, gender, and type and dose of medication. Alcohol use influenced the thalamic response measure, but covariates did not alter the relation between greater indices of brain aging and less successful blood pressure response to treatment. The state of the brain may be an important factor in the remediation of blood pressure. |
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Authors:
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J Richard Jennings; Matthew F Muldoon; Ellen M Whyte; Joelle Scanlon; Julie Price; Carolyn C Meltzer |
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Publication Detail:
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Type: Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural Date: 2008-11-03 |
Journal Detail:
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Title: Hypertension Volume: 52 ISSN: 1524-4563 ISO Abbreviation: Hypertension Publication Date: 2008 Dec |
Date Detail:
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Created Date: 2008-11-21 Completed Date: 2008-12-31 Revised Date: 2012-01-26 |
Medline Journal Info:
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Nlm Unique ID: 7906255 Medline TA: Hypertension Country: United States |
Other Details:
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Languages: eng Pagination: 1113-9 Citation Subset: IM |
Affiliation:
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Departments of Psychiatry and Psychology, University of Pittsburgh, PA, USA. JenningsJR@upmc.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aging Antihypertensive Agents / administration & dosage* Atenolol / administration & dosage Blood Pressure / drug effects Brain / pathology, radionuclide imaging Cerebrovascular Circulation / drug effects Cognition Disorders / pathology, radionuclide imaging* Female Humans Hypertension / drug therapy, pathology, radionuclide imaging* Lisinopril / administration & dosage* Magnetic Resonance Imaging Male Memory, Short-Term Middle Aged Neuropsychological Tests Positron-Emission Tomography* Predictive Value of Tests Regression Analysis |
| Grant Support | |
ID/Acronym/Agency:
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057529//PHS HHS; HL076852/076858/HL/NHLBI NIH HHS; MH067710/MH/NIMH NIH HHS; R01 HL057529-05/HL/NHLBI NIH HHS; R01 HL057529-06/HL/NHLBI NIH HHS; R01 HL057529-07/HL/NHLBI NIH HHS; R01 HL057529-08/HL/NHLBI NIH HHS; R01 HL101959-02/HL/NHLBI NIH HHS; R01 HL101959-03/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Antihypertensive Agents; 29122-68-7/Atenolol; 83915-83-7/Lisinopril |
| Comments/Corrections | |
Comment In:
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Hypertension. 2008 Dec;52(6):1014-5
[PMID:
18981318
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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