Document Detail

Brain hypothermia relieves severe brain swelling following acute major cerebral artery occlusion.
MedLine Citation:
PMID:  11255629     Owner:  NLM     Status:  MEDLINE    
Seven patients were treated with brain hypothermia following acute major cerebral artery occlusion to utilize the suppressive effect against brain swelling. Five patients had internal carotid and two had proximal middle cerebral artery occlusion. Except for the first two cases, hypothermia was introduced early and the temperature reached 35.0 degrees C within 6 hours after the onset. The core temperature finally stabilized between 32 degrees C to 34 degrees C. Hypothermia had a suppressive effect against brain swelling and the temperature showed a significant correlation to intracranial pressure. Recurrence of brain swelling was observed during the rewarming process, but two patients became independent and three patients were moderately disabled in wheelchairs. Only two patients died. Brain hypothermia is an effective treatment for acute major cerebral artery occlusion through the relief of brain swelling. The overall outcome may be improved by combining brain hypothermia with other conventional therapies such as osmotherapy and external decompression implemented with an extended period of rewarming.
Y Kurokawa; H Kano; Y Yonemasu; T Sasaki; K Inaba; T Uede
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Neurologia medico-chirurgica     Volume:  41     ISSN:  0470-8105     ISO Abbreviation:  Neurol. Med. Chir. (Tokyo)     Publication Date:  2001 Feb 
Date Detail:
Created Date:  2001-03-20     Completed Date:  2001-05-03     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0400775     Medline TA:  Neurol Med Chir (Tokyo)     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  53-61; discussion 61-2     Citation Subset:  IM    
Division of Neurosurgery, Obihiro Neurosurgical Hospital, Obihiro, Japan.
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MeSH Terms
Acute Disease
Brain Edema / radiography,  therapy*
Carotid Artery, Internal / radiography
Carotid Stenosis / radiography,  therapy*
Hypothermia, Induced*
Infarction, Middle Cerebral Artery / radiography,  therapy*
Middle Aged
Tomography, X-Ray Computed

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