| Brain and hippocampus fatty acid composition in phospholipid classes of aged-relative cognitive deficit rats. | |
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MedLine Citation:
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PMID: 11334555 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The aim of this work was to study the composition of long chain fatty acids and the n-6 and n-3 fatty acid ratios in aged and young Wistar rats in brain and hippocampus, related to relative cognitive deficits. The aged animals showed cognitive deficits during acquisition of a memory task (delayed alternation). In brain, results showed a decrease in palmitoleic and palmitic acid percentages in all the studied phospholipid classes and in the phosphatidylserine and phosphatidylcholine classes, respectively, in old rats, compared to the young ones. There was also an increase in oleic and stearic acid amounts in the sphingomyelin, phosphatidylserine and phosphatidylinositol classes and in the phosphatidylserine and phosphatidylcholine classes, respectively. Arachidonic acid amount was decreased in old rats, compared to the young ones, in the phosphatidylserine and phosphatidylinositol classes. Total n-6 and n-3 fatty acid amounts were both decreased in all phospholipid classes, with a stable n-6/n-3 ratio. Our results confirm that arachidonic acid concentration is decreased in aged rats and that this reduction, more significant in phosphatidylserine and phosphatidylinositol classes, should be related to the fact that low concentrations of arachidonic acid are observed during activation of glutamate receptor. |
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Authors:
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L Ulmann; V Mimouni; S Roux; R Porsolt; J P Poisson |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Prostaglandins, leukotrienes, and essential fatty acids Volume: 64 ISSN: 0952-3278 ISO Abbreviation: Prostaglandins Leukot. Essent. Fatty Acids Publication Date: 2001 Mar |
Date Detail:
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Created Date: 2001-05-03 Completed Date: 2001-07-26 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8802730 Medline TA: Prostaglandins Leukot Essent Fatty Acids Country: Scotland |
Other Details:
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Languages: eng Pagination: 189-95 Citation Subset: IM |
Copyright Information:
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Copyright 2001 Harcourt Publishers Ltd. |
Affiliation:
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IUT Département Génie Biologique, Université du Maine, 53020 Laval Cedex 9, France.lulman@univ-lemans.fr |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Age Factors Aging* Animals Behavior, Animal Body Weight Brain / metabolism* Diet Fatty Acids / biosynthesis* Fatty Acids, Monounsaturated / metabolism Hippocampus / metabolism* Male Memory Oleic Acids / metabolism Organ Size Palmitic Acid / metabolism Phospholipids / metabolism* Rats Rats, Wistar Receptors, Glutamate / metabolism Stearic Acids / metabolism Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Fatty Acids; 0/Fatty Acids, Monounsaturated; 0/Oleic Acids; 0/Phospholipids; 0/Receptors, Glutamate; 0/Stearic Acids; 2091-29-4/palmitoleic acid; 57-10-3/Palmitic Acid; 57-11-4/stearic acid |
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