Document Detail

Brain hemorrhages in cocaine-exposed human fetuses.
MedLine Citation:
PMID:  1957258     Owner:  NLM     Status:  MEDLINE    
Autopsies of 4 fetuses exposed to maternal cocaine are reported. Brain examination revealed hemorrhages in 3 of the fetuses involving the germinal matrix. The hemorrhages resembled subependymal germinal matrix hemorrhages seen as postnatal complications in premature infants with idiopathic respiratory distress syndrome. One of the placentas had sonographic evidence of abruption which could not be confirmed pathologically. The findings are discussed in light of reports of neurobehavioral deficits and other congenital anomalies in children and animals exposed to cocaine in utero. Speculations about the pathophysiologic events leading to these findings are made.
R P Kapur; C M Shaw; T H Shepard
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Teratology     Volume:  44     ISSN:  0040-3709     ISO Abbreviation:  Teratology     Publication Date:  1991 Jul 
Date Detail:
Created Date:  1991-12-30     Completed Date:  1991-12-30     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0153257     Medline TA:  Teratology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  11-8     Citation Subset:  IM    
Department of Pathology, School of Medicine, University of Washington, Seattle 98195.
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MeSH Terms
Cerebral Hemorrhage / chemically induced*,  pathology
Cocaine / adverse effects*
Fetal Diseases / chemically induced*,  pathology
Vasoconstriction / drug effects
Reg. No./Substance:

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