Document Detail

Brain hemorrhage associated with methanol poisoning.
MedLine Citation:
PMID:  3342624     Owner:  NLM     Status:  MEDLINE    
We recently treated seven patients who were victims of accidental methanol intoxication. Five of the seven patients died within 72 h of hospital admission. The two survivors were discharged from the hospital without visual or neurologic impairment. Hemorrhagic necrosis of the brain was found on CT scan and at autopsy in two patients who died. This complication of methanol intoxication prompted us to review our experience with this poison since 1980. Of 45 methanol intoxication patients treated in our ICU, CT scan was performed in 21, and brain hemorrhage was documented in six, thereby giving an incidence of at least six of 45 or 13.5%. Although hemorrhagic and nonhemorrhagic putamenal necrosis has been described from methanol poisoning previously, we postulate that heparinization during hemodialysis may contribute to brain hemorrhage complicating methanol poisoning and recommend the use of artificial kidneys with albumin-primed biocompatible membranes so that heparin administration during hemodialysis can be minimized.
P T Phang; L Passerini; B Mielke; R Berendt; E G King
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Critical care medicine     Volume:  16     ISSN:  0090-3493     ISO Abbreviation:  Crit. Care Med.     Publication Date:  1988 Feb 
Date Detail:
Created Date:  1988-03-28     Completed Date:  1988-03-28     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0355501     Medline TA:  Crit Care Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  137-40     Citation Subset:  AIM; IM    
Division of Critical Care Medicine, University of Alberta, Edmonton, Canada.
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MeSH Terms
Brain / pathology
Cerebral Hemorrhage / etiology*,  pathology
Heparin / adverse effects
Methanol / pharmacokinetics,  poisoning*
Renal Dialysis / adverse effects
Reg. No./Substance:
67-56-1/Methanol; 9005-49-6/Heparin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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