Document Detail

Brain hemodynamic changes in preterm infants after maintenance dose caffeine and aminophylline treatment.
MedLine Citation:
PMID:  10878419     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To investigate the acute effects of low-dose caffeine and aminophylline on cerebral blood flow in preterm infants, using both near-infrared spectroscopy (NIRS) and cerebral Doppler ultrasonography. METHODS: Preterm infants with a gestational age of <32 weeks and birth weight of <1,500 g were randomized to receive either caffeine or aminophylline treatment for apnea of prematurity. The study period went from 30 min before to 60 min after the administration of the maintenance dose of pure caffeine (2.5 mg/kg once a day) or aminophylline (1.25 mg/kg twice a day). NIRS was used to measure changes in oxygenated hemoglobin (O(2)Hb), deoxygenated hemoglobin (HHb), oxidized-reduced cytochrome aa3 (CtOx), and mean cerebral oxygen saturation (SmO(2) = O(2)Hb/total Hb). Changes in cerebral blood volume (DeltaCBV) after caffeine or aminophylline administration were calculated. Cerebral blood flow velocity (CBV) in the pericallosal artery was evaluated by cerebral Doppler ultrasounds. RESULTS: Data collected by NIRS and cerebral Doppler ultrasounds did not show significant differences before and after caffeine treatment. We observed a significant increase in O(2)Hb and HHb concentration and in CBV at 30 min after the infusion of aminophylline, which tended to return to baseline at the end of the study period. CONCLUSION: Caffeine does not significantly affect brain hemodynamics, while aminophylline induces a significant transient increase in O(2)Hb and HHb concentration and CBV.
C Dani; G Bertini; M F Reali; M Tronchin; L Wiechmann; E Martelli; F F Rubaltelli
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Biology of the neonate     Volume:  78     ISSN:  0006-3126     ISO Abbreviation:  Biol. Neonate     Publication Date:  2000 Jul 
Date Detail:
Created Date:  2000-08-11     Completed Date:  2000-08-11     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0247551     Medline TA:  Biol Neonate     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  27-32     Citation Subset:  IM    
Copyright Information:
Copyright 2000 S. Karger AG, Basel
Division of Neonatology, Careggi University Hospital, Florence, Italy.
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MeSH Terms
Aminophylline / administration & dosage,  adverse effects*
Apnea / drug therapy
Birth Weight
Blood Flow Velocity / drug effects
Blood Volume / drug effects
Caffeine / administration & dosage,  adverse effects*
Central Nervous System Stimulants / administration & dosage,  adverse effects*
Cerebrovascular Circulation / drug effects*
Electron Transport Complex IV / blood
Gestational Age
Hemoglobins / analysis
Infant, Newborn
Infant, Premature / physiology*
Infant, Premature, Diseases / drug therapy
Oxygen / blood
Oxyhemoglobins / analysis
Ultrasonography, Doppler
Reg. No./Substance:
0/Central Nervous System Stimulants; 0/Hemoglobins; 0/Oxyhemoglobins; 317-34-0/Aminophylline; 58-08-2/Caffeine; 7782-44-7/Oxygen; 9008-02-0/deoxyhemoglobin; EC Transport Complex IV

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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