Document Detail


Brain hemodynamic changes in preterm infants after maintenance dose caffeine and aminophylline treatment.
MedLine Citation:
PMID:  10878419     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To investigate the acute effects of low-dose caffeine and aminophylline on cerebral blood flow in preterm infants, using both near-infrared spectroscopy (NIRS) and cerebral Doppler ultrasonography. METHODS: Preterm infants with a gestational age of <32 weeks and birth weight of <1,500 g were randomized to receive either caffeine or aminophylline treatment for apnea of prematurity. The study period went from 30 min before to 60 min after the administration of the maintenance dose of pure caffeine (2.5 mg/kg once a day) or aminophylline (1.25 mg/kg twice a day). NIRS was used to measure changes in oxygenated hemoglobin (O(2)Hb), deoxygenated hemoglobin (HHb), oxidized-reduced cytochrome aa3 (CtOx), and mean cerebral oxygen saturation (SmO(2) = O(2)Hb/total Hb). Changes in cerebral blood volume (DeltaCBV) after caffeine or aminophylline administration were calculated. Cerebral blood flow velocity (CBV) in the pericallosal artery was evaluated by cerebral Doppler ultrasounds. RESULTS: Data collected by NIRS and cerebral Doppler ultrasounds did not show significant differences before and after caffeine treatment. We observed a significant increase in O(2)Hb and HHb concentration and in CBV at 30 min after the infusion of aminophylline, which tended to return to baseline at the end of the study period. CONCLUSION: Caffeine does not significantly affect brain hemodynamics, while aminophylline induces a significant transient increase in O(2)Hb and HHb concentration and CBV.
Authors:
C Dani; G Bertini; M F Reali; M Tronchin; L Wiechmann; E Martelli; F F Rubaltelli
Related Documents :
17382619 - A randomized clinical trial of regional cerebral perfusion versus deep hypothermic circ...
16608549 - Prolonged coexistence of transient and permanent circuitry elements in the developing c...
12111299 - Molecular analysis of thrombophilic risk factors in patients with dural arteriovenous f...
6508239 - Perinatal cerebral infarction.
18787659 - Cerebral ventricular volume and temperamental difficulties in infancy. the generation r...
11320039 - Ultrasound diagnosis and neurodevelopmental outcome of localised and extensive cystic p...
3626909 - Rotational delivery with kielland's forceps.
10562869 - Deprivation and excess winter mortality.
3299999 - The effect of maternal illness on perinatal health.
Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Biology of the neonate     Volume:  78     ISSN:  0006-3126     ISO Abbreviation:  Biol. Neonate     Publication Date:  2000 Jul 
Date Detail:
Created Date:  2000-08-11     Completed Date:  2000-08-11     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0247551     Medline TA:  Biol Neonate     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  27-32     Citation Subset:  IM    
Copyright Information:
Copyright 2000 S. Karger AG, Basel
Affiliation:
Division of Neonatology, Careggi University Hospital, Florence, Italy. cdani@unifi.it
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Aminophylline / administration & dosage,  adverse effects*
Apnea / drug therapy
Birth Weight
Blood Flow Velocity / drug effects
Blood Volume / drug effects
Caffeine / administration & dosage,  adverse effects*
Central Nervous System Stimulants / administration & dosage,  adverse effects*
Cerebrovascular Circulation / drug effects*
Electron Transport Complex IV / blood
Gestational Age
Hemoglobins / analysis
Humans
Infant, Newborn
Infant, Premature / physiology*
Infant, Premature, Diseases / drug therapy
Oxygen / blood
Oxyhemoglobins / analysis
Ultrasonography, Doppler
Chemical
Reg. No./Substance:
0/Central Nervous System Stimulants; 0/Hemoglobins; 0/Oxyhemoglobins; 317-34-0/Aminophylline; 58-08-2/Caffeine; 7782-44-7/Oxygen; 9008-02-0/deoxyhemoglobin; EC 1.9.3.1/Electron Transport Complex IV

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Cortisol and 17-hydroxyprogesterone levels in saliva of healthy neonates: normative data and relatio...
Next Document:  Effects of oxytocin treatment in early life on body weight and corticosterone in adult offspring fro...