| Brain hemodynamic changes in preterm infants after maintenance dose caffeine and aminophylline treatment. | |
| | |
MedLine Citation:
|
PMID: 10878419 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVE: To investigate the acute effects of low-dose caffeine and aminophylline on cerebral blood flow in preterm infants, using both near-infrared spectroscopy (NIRS) and cerebral Doppler ultrasonography. METHODS: Preterm infants with a gestational age of <32 weeks and birth weight of <1,500 g were randomized to receive either caffeine or aminophylline treatment for apnea of prematurity. The study period went from 30 min before to 60 min after the administration of the maintenance dose of pure caffeine (2.5 mg/kg once a day) or aminophylline (1.25 mg/kg twice a day). NIRS was used to measure changes in oxygenated hemoglobin (O(2)Hb), deoxygenated hemoglobin (HHb), oxidized-reduced cytochrome aa3 (CtOx), and mean cerebral oxygen saturation (SmO(2) = O(2)Hb/total Hb). Changes in cerebral blood volume (DeltaCBV) after caffeine or aminophylline administration were calculated. Cerebral blood flow velocity (CBV) in the pericallosal artery was evaluated by cerebral Doppler ultrasounds. RESULTS: Data collected by NIRS and cerebral Doppler ultrasounds did not show significant differences before and after caffeine treatment. We observed a significant increase in O(2)Hb and HHb concentration and in CBV at 30 min after the infusion of aminophylline, which tended to return to baseline at the end of the study period. CONCLUSION: Caffeine does not significantly affect brain hemodynamics, while aminophylline induces a significant transient increase in O(2)Hb and HHb concentration and CBV. |
| | |
Authors:
|
C Dani; G Bertini; M F Reali; M Tronchin; L Wiechmann; E Martelli; F F Rubaltelli |
Related Documents
:
|
7369719 - Familial stroke syndrome associated with mitral valve prolapse. 11593379 - Bilateral thalamic lesions in a newborn with intrauterine asphyxia after maternal cardi... 21125559 - Health outcomes among infants born to women deployed to united states military operatio... 8848329 - Cerebral metabolism within 18 hours of birth asphyxia: a proton magnetic resonance spec... 19036619 - Safety of botulinum toxin type a in children younger than 2 years. 976279 - Analysis of etiologic factors in cerebral palsy with severe mental retardation. i. anal... 18336439 - Developmental origins theory from prematurity to adult disease. 18306989 - Prediction of early death in severe acute pancreatitis. 2717259 - Prognosis of newborn infants with hypoxic-ischemic brain injury assessed by phosphorus ... |
Publication Detail:
|
Type: Clinical Trial; Journal Article; Randomized Controlled Trial |
Journal Detail:
|
Title: Biology of the neonate Volume: 78 ISSN: 0006-3126 ISO Abbreviation: Biol. Neonate Publication Date: 2000 Jul |
Date Detail:
|
Created Date: 2000-08-11 Completed Date: 2000-08-11 Revised Date: 2004-11-17 |
Medline Journal Info:
|
Nlm Unique ID: 0247551 Medline TA: Biol Neonate Country: SWITZERLAND |
Other Details:
|
Languages: eng Pagination: 27-32 Citation Subset: IM |
Copyright Information:
|
Copyright 2000 S. Karger AG, Basel |
Affiliation:
|
Division of Neonatology, Careggi University Hospital, Florence, Italy. cdani@unifi.it |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Aminophylline
/
administration & dosage,
adverse effects* Apnea / drug therapy Birth Weight Blood Flow Velocity / drug effects Blood Volume / drug effects Caffeine / administration & dosage, adverse effects* Central Nervous System Stimulants / administration & dosage, adverse effects* Cerebrovascular Circulation / drug effects* Electron Transport Complex IV / blood Gestational Age Hemoglobins / analysis Humans Infant, Newborn Infant, Premature / physiology* Infant, Premature, Diseases / drug therapy Oxygen / blood Oxyhemoglobins / analysis Ultrasonography, Doppler |
| Chemical | |
Reg. No./Substance:
|
0/Central Nervous System Stimulants; 0/Hemoglobins; 0/Oxyhemoglobins; 317-34-0/Aminophylline; 58-08-2/Caffeine; 7782-44-7/Oxygen; 9008-02-0/deoxyhemoglobin; EC 1.9.3.1/Electron Transport Complex IV |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Cortisol and 17-hydroxyprogesterone levels in saliva of healthy neonates: normative data and relatio...
Next Document: Effects of oxytocin treatment in early life on body weight and corticosterone in adult offspring fro...