Document Detail

Brain haemodynamic effects of nasal continuous airway pressure in preterm infants of less than 30 weeks' gestation.
MedLine Citation:
PMID:  17714539     Owner:  NLM     Status:  MEDLINE    
AIM: To evaluate the hypothesis that increasing levels of nasal continuous positive airway pressure (NCPAP) may decrease cerebral blood volume (CBV) and cerebral oxygenation in infants with gestational age (GA) less than 30 weeks. METHODS: We prospectively studied a cohort of preterm infants treated with NCPAP using near-infrared spectroscopy (NIRS). The pressure limit of NCPAP was set at 2, 4, 6 and again 2 cm H(2)O for 30 min. RESULTS: Changes of pressure levels were not followed by significant changes of oxygenated haemoglobin (O(2)Hb), deoxygenated haemoglobin (HHb), cerebral intravascular oxygenation (HbD), oxidized-reduced cytochrome aa3 (CtOx), tissue oxygenation index (TOI), tissue haemoglobin index (THI) and cerebral blood volume (DeltaCBV). CONCLUSION: NCPAP at 2-6 cm H(2)O pressure levels did not affect cerebral oxygenation and CBV. These findings are reassuring and confirm the safety of NCPAP in preterm infants with GA less than 30 weeks.
Carlo Dani; Giovanna Bertini; Alessandra Cecchi; Iuri Corsini; Simone Pratesi; Firmino F Rubaltelli
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Publication Detail:
Type:  Comparative Study; Journal Article     Date:  2007-08-20
Journal Detail:
Title:  Acta paediatrica (Oslo, Norway : 1992)     Volume:  96     ISSN:  0803-5253     ISO Abbreviation:  Acta Paediatr.     Publication Date:  2007 Oct 
Date Detail:
Created Date:  2007-09-20     Completed Date:  2008-01-25     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9205968     Medline TA:  Acta Paediatr     Country:  Norway    
Other Details:
Languages:  eng     Pagination:  1421-5     Citation Subset:  IM    
Section of Neonatology, Department of Surgical and Medical Critical Care, Careggi University Hospital of Florence, Viale Morgagni 85, 50134 Florence, Italy.
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MeSH Terms
Brain / blood supply*
Cerebrovascular Circulation / physiology*
Continuous Positive Airway Pressure*
Gestational Age*
Health Status Indicators
Hemoglobins / analysis,  metabolism*
Infant, Newborn
Infant, Premature*
Prospective Studies
Spectroscopy, Near-Infrared
Reg. No./Substance:

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